The Whitman Lab elucidates how amino acid insufficiency activates signaling through ribosome collisions. November 10, 2025 GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling
Moazed Lab Identifies Pathways for Heterochromatin Establishment and Inheritance November 7, 2025 Requirements for establishment and epigenetic stability of mammalian heterochromatin
Cell Bio faculty members develop a flexible competency framework to optimize life science training October 28, 2025 A flexible competency-based framework designed to align program objectives, curricula, and mentoring expectations
Chouchani Lab uses covariation MS to uncover a protein controlling cysteine catabolism October 22, 2025 A MS-based approach that leverages genetic diversity to nominate functional relationships between metabolites and proteins in living tissues.
Shao Lab visualizes the redox-active protein TXNL1 on proteasomes August 22, 2025 Structure of the TXNL1-bound proteasome
Gu Lab provides the mechanism for the midnolin-proteasome pathway and its implications in multiple myeloma July 1, 2025 Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
Allard Lab uncovers animal organelle that sustains photosynthesis in stolen chloroplasts June 27, 2025 A host organelle integrates stolen chloroplasts for animal photosynthesis
Harper Lab identifies a lysosomal homeostatic response induced by TRPML1 activation June 23, 2025 DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation
Harper Lab charts the structural protein complex landscape of human endosomes May 30, 2025 EndoMAP.v1 charts the structural landscape of human early endosome complexes
Rapoport lab discovers how ERAD of misfolded glycoproteins is initiated March 17, 2025 Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase
Puigserver Lab harnesses mitochondrial dysfunction for anti-cancer effects February 4, 2025 Selective deficiency of mitochondrialrespiratory complex I subunits Ndufs4/6causes tumor immunogenicity
Harper Lab Uses Advanced Proteomic and Lipidomic Platforms to Decode Lysosomal Storage Diseases January 31, 2025 Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST
