Recent Research

TXNL1 interactions with the 19S regulatory particle of proteasomes are required for its ubiquitin-independent degradation upon cellular exposure to arsenite.

Shao Lab visualizes the redox-active protein TXNL1 on proteasomes

August 22, 2025

Structure of the TXNL1-bound proteasome

Model for how the midnolin-proteasome pathway degrades nuclear proteins independently of ubiquitination

Gu Lab provides the mechanism for the midnolin-proteasome pathway and its implications in multiple myeloma

July 1, 2025

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma

Seaslug with enlarged keptosome image

Allard Lab uncovers animal organelle that sustains photosynthesis in stolen chloroplasts

June 27, 2025

A host organelle integrates stolen chloroplasts for animal photosynthesis

TRPML1 activation induces lysosomal cation efflux, leading to pH perturbation and CASM.

Harper Lab identifies a lysosomal homeostatic response induced by TRPML1 activation

June 23, 2025

DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation

Protein-interaction landscape of human endosomes and 3D structural model of a new protein complex

Harper Lab charts the structural protein complex landscape of human endosomes

May 30, 2025

EndoMAP.v1 charts the structural landscape of human early endosome complexes

Steps during the initiation of ERAD of a misfolded glycoprotein.

Rapoport lab discovers how ERAD of misfolded glycoproteins is initiated

March 17, 2025

Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase

Graphical abstract displaying how altered mitochondrial complex I activity leads to tumor immunogenicity

Puigserver Lab harnesses mitochondrial dysfunction for anti-cancer effects

February 4, 2025

Selective deficiency of mitochondrialrespiratory complex I subunits Ndufs4/6causes tumor immunogenicity