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Open positions

  • Research Associate positions - King Lab

    Position Descriptions

    The King Laboratory in the Cell Biology Department at Harvard Medical School is seeking two highly qualified individuals to join our research team as Associates focused on the problem of how protein degradation controls cell division, and how this process is perturbed in cancer. Our lab integrates cutting-edge approaches including live cell imaging, biochemistry, chemical biology and quantitative proteomics to understand how the activity of the ubiquitin-proteasome system is regulated during cell division.          

    Each associate would have their own research project, collaborating with laboratory members and interacting directly with the PI, Dr. Randy King, much like a graduate student, on a daily basis. These are ideal positions for students aiming to enter graduate and/or medical school programs following their tenure in the laboratory. We ask candidates to commit to no less than 2 years in the lab to allow for maximum experience and contributions.

    General Qualifications

    Successful candidates will have a BA or BS degree in the biological or chemical sciences (Biology, Chemistry, Cell Biology, Biochemistry, Molecular Biology, Genetics, Neuroscience, Immunology, Pharmacology). Candidates must be self-motivated, able to work independently as well as part of a team, have excellent communication and interpersonal skills, pay attention to detail, and be highly organized.

    Position 1: Cell-Based Analysis of the Ubiquitin-Proteasome System in Cell Division

    Working with the PI, this associate will design and execute experiments to study the role of protein degradation in the control of cell division. The associate will develop and maintain human cell lines that will be the focus of analysis. Long-term time-lapse microscopy will be used to analyze the effects of different chemical and genetic perturbations on cell division. The associate will also prepare cellular samples for analysis by quantitative mass spectrometry and western blotting. Specific qualifications include:

    • Laboratory experience with cell culture is essential
    • Experience with genetic manipulation of cultured cells (CRISPR-based gene editing, expression of reporter genes, or siRNA-mediated knockdown) is preferred
    • Experience with microscopy is preferred
    • Familiarity with molecular biology techiques (cloning, PCR) is preferred

    Position 2: Biochemical and Mechanistic Analysis of the Ubiquitin-Proteasome System

    Working with the PI, this associate will design and execute experiments to study the mechanism of action of ubiquitin ligases and deubiquitylating enzymes using Xenopus cell cycle extracts. The associate will prepare extracts from Xenopus eggs and express recombinant proteins for functional characterization. Experiments will be analyzed by autoradiography, western blotting and quantitative proteomics.

    • Experience with general biochemical lab techniques is essential (preparation of buffers, SDS-gel electrophoresis, western blotting)
    • Experience with expression and purification of recombinant proteins is preferred
    • Familiarity with molecular biology techiques (cloning, PCR) is preferred

    Application Instructions

    If you are interested in this exciting career opportunity to work with the vibrant community of cell biologists at Harvard Medical School, please email Dr. Randy King: randy_king@hms.harvard.edu, with a cover letter and CV including the names and contact information for three references. More information about the lab can be found at: https://king.med.harvard.edu/.

    Commitment to Equity, Diversity, Inclusion, and Belonging

    Harvard University views equity, diversity, inclusion, and belonging as the pathway to achieving inclusive excellence and fostering a campus culture where everyone can thrive. We strive to create a community that draws upon the widest possible pool of talent to unify excellence and diversity while fully embracing individuals from varied backgrounds, cultures, races, identities, life experiences, perspectives, beliefs, and values.

    EEO Statement

    We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law.

    COVID-19

    The University requires all Harvard community members to be fully vaccinated against COVID-19 and remain up to date with COVID-19 vaccine boosters, as detailed in Harvard’s Vaccine & Booster Requirements. Individuals may claim exemption from the vaccine requirement for medical or religious reasons. More information regarding the University’s COVID vaccination requirement, exemptions, and verification of vaccination status may be found at the University’s “COVID-19 Vaccine Information” webpage: http://www.harvard.edu/coronavirus/covid-19-vaccine-information/

  • Postdoctoral Fellow Position - Danial Lab

    Postdoctoral Fellow Position in Molecular Metabolism

    Description: 

    A postdoctoral position in molecular metabolism is available in the laboratory of Nika Danial, PhD. The Danial lab investigates the metabolic mechanisms that regulate cellular and organismal adaptation to physiologic and pathologic stress conditions (https://www.daniallab-dana-farber.org/). Within this context, we study fundamental aspects of metabolic biology, including causes and consequences of cellular fuel utilization patterns and how processing of carbon substrates translates into specific metabolic signals that shape cell fate and function. To this end, we apply multi-disciplinary approaches that draw on biochemistry, mitochondrial physiology, chemical biology, proteomics and metabolomics. This research program has led to advancements in understanding anabolic and catabolic mechanisms that link altered cellular fuel usage to diseases such as cancer, diabetes and seizure disorders. 

    Several projects are currently available, including investigation of 1) metabolic crosstalks between inflammatory immune cells and target tissues; 2) cell autonomous and nonautonomous mechanisms underlying fuel utilization patterns and their control of tumor growth; 3) transcriptional control of lipid homeostasis by glucose/carbohydrates; and 4) glucose versus ketone body fuel decisions and the control of neuronal fate and function.

    Qualifications:

    Candidates must hold a Ph.D. and/or M.D. and have excellent track record of scientific research supported by peer-reviewed publications. This position requires basic cell and molecular biology experience. Background in metabolic biochemistry and/or mass spectrometry-based metabolomics and experience with mouse models are especially preferred.

    Environment:

    Located in Boston, Harvard Medical School and Dana-Farber Cancer Institute offers a world-class research environment along with being part of the vibrant research community of the Greater Boston/Cambridge area.

    Availability:

    Immediate

    To apply:

    Qualified candidates should send a Cover letter, CV and contact information for three references to Dr. Nika Danial (nika_danial@dfci.harvard.edu), and also apply to: https://careers.dana-farber.org/job/research-fellow-in-dr-nika-danials-laboratory-fellowships-boston-ma-25036/