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Open positions

  • Postdoctoral Fellow Position - Danial Lab

    Postdoctoral Fellow Position in Molecular Metabolism

    Description: 

    A postdoctoral position in molecular metabolism is available in the laboratory of Nika Danial, PhD. The Danial lab investigates the metabolic mechanisms that regulate cellular and organismal adaptation to physiologic and pathologic stress conditions (https://www.daniallab-dana-farber.org/). Within this context, we study fundamental aspects of metabolic biology, including causes and consequences of cellular fuel utilization patterns and how processing of carbon substrates translates into specific metabolic signals that shape cell fate and function. To this end, we apply multi-disciplinary approaches that draw on biochemistry, mitochondrial physiology, chemical biology, proteomics and metabolomics. This research program has led to advancements in understanding anabolic and catabolic mechanisms that link altered cellular fuel usage to diseases such as cancer, diabetes and seizure disorders. 

    Several projects are currently available, including investigation of 1) metabolic crosstalks between inflammatory immune cells and target tissues; 2) cell autonomous and nonautonomous mechanisms underlying fuel utilization patterns and their control of tumor growth; 3) transcriptional control of lipid homeostasis by glucose/carbohydrates; and 4) glucose versus ketone body fuel decisions and the control of neuronal fate and function.

    Qualifications:

    Candidates must hold a Ph.D. and/or M.D. and have excellent track record of scientific research supported by peer-reviewed publications. This position requires basic cell and molecular biology experience. Background in metabolic biochemistry and/or mass spectrometry-based metabolomics and experience with mouse models are especially preferred.

    Environment:

    Located in Boston, Harvard Medical School and Dana-Farber Cancer Institute offers a world-class research environment along with being part of the vibrant research community of the Greater Boston/Cambridge area.

    Availability:

    Immediate

    To apply:

    Qualified candidates should send a Cover letter, CV and contact information for three references to Dr. Nika Danial (nika_danial@dfci.harvard.edu), and also apply to: https://careers.dana-farber.org/job/research-fellow-in-dr-nika-danials-laboratory-fellowships-boston-ma-25036/

  • Liquid Chromatography-Mass Spectrometry Fellow

    The Department of Cell Biology at Harvard Medical School is seeking a Liquid Chromatography-Mass Spectrometry Fellow. The postdoctoral fellow will work with a team of scientists who study the role of metabolism in cancer, obesity, aging, and immune function. 

    The job responsibilities include but are not limited to: 

    • Leading the development and optimization of state-of-the-art mass spectrometry methods to identify small molecule metabolites
    • Work with lab members and collaborators to help design effective experiments, assist with metabolite extractions, analyze samples, and interpret and communicate results 
    • Monitor instrument performance and diagnose performance issues, and store associated data
    • Maintain mass spectrometry instrumentation and the associated analytical software 
    • Implement new methods and approaches within our analytical pipeline as necessary

    Job requirements:

    • PhD in Analytical Chemistry or related fields 
    • Direct hands-on experience with sample preparation and analysis to detect small molecule metabolites from complex biological matrices 
    • Experience with chromatography and MS method development, strong familiarity and aptitude with LC and MS instrumentation, and experience in mass spectrometry data analysis and software 
    • Knowledge of bioanalytical principles, separation science, mass spectrometry and small molecule characterization
    • Strong computer skills and experience with software-driven metabolite profiling (Thermo Scientific TraceFinder, Compound Discoverer, Agilent MassHunter)
    • Candidate must be highly organized with excellent time management skills, the ability to multi-task, effectively manage changing priorities and remain calm under pressure
    • Excellent written and verbal communication skills to liaise with internal and external MS users in a collaborative, international multi-disciplinary team environment
    • Highly detail oriented with a critical eye for optimizing workflows 

    If you are interested in this exciting career opportunity to work with the vibrant community of Cell Biologists at Harvard Medical School, please email a cover letter and CV including the names and contact information for three references to Marcia_Haigis@hms.harvard.edu and Shakchhi_Joshi@hms.harvard.edu.

     EEO Statement

    We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law.