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Recent Research

Insertion of the TOM70 receptor into the outer mitochondrial membrane (OMM) by the cytosolic chaperone PPID controls mitochondrial function and sustains cellular bioenergetics and cellular homeostasis under conditions of dietary lipid overloads.

Puigserver Lab identifies a chaperone-assisted mechanism controlling protein insertion into mitochondria

January 31, 2025

Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity

ZnCPT - The zinc-binding cysteine proteome (Logo)

The Chouchani Lab establishes the human zinc-binding cysteine proteome.

January 14, 2025

The human zinc-binding cysteine proteome (ZnCPT)

During transcription by RNA Polymerase II, FACT and RTF1 facilitate histone transfer and nucleosome reassembly, while SPT6 alleviates SETD2 auto-inhibition, enabling SETD2 to deposit H3K36me3 on the upstream, reassembled nucleosome.

Farnung Lab uses cryo-EM to explain why H3K36me3 is found only in gene bodies

January 13, 2025

Structural basis of H3K36 trimethylation by SETD2 during chromatin transcription

Proposed model for role of CNA cells during tumorigenesis

Brugge lab and collaborators use single-cell approaches to identify early cancer-like alterations in normal and high-risk breast epithelial cells

November 25, 2024

Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations

Mrc1 acts as a parental histone distribution site

Moazed Lab Discovers a New Mechanism for Parental Histone Recycling and Epigenetic Inheritance

November 19, 2024

A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance

New mechanistic model for BRCA1 hereditary breast cancer

Brugge Lab found new insights into hereditary cancer risk

November 15, 2024

Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer.

anti-diabetic small molecules targeting selective protein lysine acetylation

Puigserver lab maps novel anti-diabetic metabolic routes that re-direct lactate and gluconeogenic carbon substrates to mitochondrial oxidation

November 8, 2024

Design of anti-diabetic small molecules targeting selective protein lysine acetylation that inhibit liver glucose production through complete lactate oxidation

Structural Basis of Mitochondrial Respiratory Complex Adaptation to Cold Temperatures

Puigserver Lab resolves highly active electron transfer structures of respiratory complexes I:III2 in cold temperatures

November 8, 2024

Under cold conditions, mitochondrial phospholipids re-structure brown fat respiratory complexes promoting the rotation of CIII2 in CI:III2 assemblies and increasing electron transfer necessary for energy expenditure and maintenance of body temperature.

a novel model for how the 26S proteasome and Cdc48 ATPase complex cooperate in protein degradation

Rapoport Lab reveals the bidirectional substrate shuttling mechanism of the 26S proteasome and the Cdc48 ATPase

July 11, 2024

Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation

Two possible models for the function of Rop1 in autophagosome formation.

Rapoport lab shows that a conserved membrane-curvature generating protein functions in autophagy

November 3, 2023

A conserved membrane curvature-generating protein is crucial for autophagosome formation in fission yeast

ZFAND5 stimulates Ub-conjugate degradation through a multistep reaction cycle.

Goldberg lab defines activation mechanism for the 26S proteasome by ZFAND5

October 26, 2023

ZFAND5 stimulates Ub-conjugate degradation through a multistep reaction cycle.

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