Gu Lab provides the mechanism for the midnolin-proteasome pathway and its implications in multiple myeloma July 1, 2025 Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
Allard Lab uncovers animal organelle that sustains photosynthesis in stolen chloroplasts June 27, 2025 A host organelle integrates stolen chloroplasts for animal photosynthesis
Harper Lab identifies a lysosomal homeostatic response induced by TRPML1 activation June 23, 2025 DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation
Harper Lab charts the structural protein complex landscape of human endosomes May 30, 2025 EndoMAP.v1 charts the structural landscape of human early endosome complexes
Rapoport lab discovers how ERAD of misfolded glycoproteins is initiated March 17, 2025 Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase
Puigserver Lab harnesses mitochondrial dysfunction for anti-cancer effects February 4, 2025 Selective deficiency of mitochondrialrespiratory complex I subunits Ndufs4/6causes tumor immunogenicity
Harper Lab Uses Advanced Proteomic and Lipidomic Platforms to Decode Lysosomal Storage Diseases January 31, 2025 Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST
Puigserver Lab identifies a chaperone-assisted mechanism controlling protein insertion into mitochondria January 31, 2025 Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity
The Chouchani Lab establishes the human zinc-binding cysteine proteome. January 14, 2025 The human zinc-binding cysteine proteome (ZnCPT)
Farnung Lab uses cryo-EM to explain why H3K36me3 is found only in gene bodies January 13, 2025 Structural basis of H3K36 trimethylation by SETD2 during chromatin transcription
Brugge lab and collaborators use single-cell approaches to identify early cancer-like alterations in normal and high-risk breast epithelial cells November 25, 2024 Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations
Moazed Lab Discovers a New Mechanism for Parental Histone Recycling and Epigenetic Inheritance November 19, 2024 A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance
