Recent Research

A schematic showing lysosomal dysfunction leading to three outcomes via nMOST: autophagy defects, mitochondrial impairments, and iron homeostasis disruption.

Harper Lab Uses Advanced Proteomic and Lipidomic Platforms to Decode Lysosomal Storage Diseases

January 31, 2025

Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST

The Chouchani Lab establishes the human zinc-binding cysteine proteome.

January 14, 2025

The human zinc-binding cysteine proteome (ZnCPT)

During transcription by RNA Polymerase II, FACT and RTF1 facilitate histone transfer and nucleosome reassembly, while SPT6 alleviates SETD2 auto-inhibition, enabling SETD2 to deposit H3K36me3 on the upstream, reassembled nucleosome.

Farnung Lab uses cryo-EM to explain why H3K36me3 is found only in gene bodies

January 13, 2025

Structural basis of H3K36 trimethylation by SETD2 during chromatin transcription

Proposed model for role of CNA cells during tumorigenesis

Brugge lab and collaborators use single-cell approaches to identify early cancer-like alterations in normal and high-risk breast epithelial cells

November 25, 2024

Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations

Mrc1 acts as a parental histone distribution site

Moazed Lab Discovers a New Mechanism for Parental Histone Recycling and Epigenetic Inheritance

November 19, 2024

A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance

New mechanistic model for BRCA1 hereditary breast cancer

Brugge Lab found new insights into hereditary cancer risk

November 15, 2024

Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer.

Structural Basis of Mitochondrial Respiratory Complex Adaptation to Cold Temperatures

Puigserver Lab resolves highly active electron transfer structures of respiratory complexes I:III2 in cold temperatures

November 8, 2024

Under cold conditions, mitochondrial phospholipids re-structure brown fat respiratory complexes promoting the rotation of CIII2 in CI:III2 assemblies and increasing electron transfer necessary for energy expenditure and maintenance of body temperature.

anti-diabetic small molecules targeting selective protein lysine acetylation

Puigserver lab maps novel anti-diabetic metabolic routes that re-direct lactate and gluconeogenic carbon substrates to mitochondrial oxidation