Rapoport Lab reveals the bidirectional substrate shuttling mechanism of the 26S proteasome and the Cdc48 ATPase July 11, 2024 Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation
Rapoport lab shows that a conserved membrane-curvature generating protein functions in autophagy November 3, 2023 A conserved membrane curvature-generating protein is crucial for autophagosome formation in fission yeast
Goldberg lab defines activation mechanism for the 26S proteasome by ZFAND5 October 26, 2023 ZFAND5 stimulates Ub-conjugate degradation through a multistep reaction cycle.
Puigserver lab identifies a key fasting-regulated protein that causes mitochondrial cristae formation and controls liver energy metabolism August 4, 2023 MIC19 protein causes mitochondrial cristae formation and remodels liver energy metabolism protecting against diet-induced obesity
Puigserver lab identifies epigenetic-dependent vulnerability to HMGR statin inhibitors in BRAF resistant melanomas. June 29, 2023 Epigenetic suppression of PGC1α (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas
Harper lab re-evaluates role of PD-risk gene in mitophagy June 23, 2023 PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems
Danial lab identifies link between mitochondrial morphology and fatty acid oxidation April 27, 2023 In a collaborative study, Danial lab reveals mitochondrial morphology controls fatty acid oxidation.
