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News

Headshot of Buyan Pan and Tajinder Ubhi

Two Cell Bio postdocs receive fellowships

January 30, 2025

Buyan Pan and Tajinder Ubhi have received American Heart Association and Helen Hay Whitney Fellowships

ZnCPT - The zinc-binding cysteine proteome (Logo)

The Chouchani Lab establishes the human zinc-binding cysteine proteome.

January 14, 2025

The human zinc-binding cysteine proteome (ZnCPT)

During transcription by RNA Polymerase II, FACT and RTF1 facilitate histone transfer and nucleosome reassembly, while SPT6 alleviates SETD2 auto-inhibition, enabling SETD2 to deposit H3K36me3 on the upstream, reassembled nucleosome.

Farnung Lab uses cryo-EM to explain why H3K36me3 is found only in gene bodies

January 13, 2025

Structural basis of H3K36 trimethylation by SETD2 during chromatin transcription

Headshot of Ed Chouchani

Recent Faculty Promotion: Ed Chouchani promoted to Professor

January 9, 2025

Congratulations to Dr. Ed Chouchani, who was was recently promoted to Professor of Cell Biology (HMS) and Professor of Cancer Biology (DFCI)!

Headshot of Fatima Alghoul

Lee Lab postdoc named Helen Gurley Brown Fellow

December 9, 2024

Fatima Alghoul and Amy Lee have been named Helen Mentors/Fellows of the Helen Gurley Brown Presidential Initiative at Dana-Farber.

Headshot of Richard Han

Lee Lab graduate student successfully defends dissertation

December 2, 2024

Congratulations to Dr. Richard Han on his successful dissertation defense!

Headshots of Zongyu Li and Ji Seul Han

Two Haigis lab postdocs receive fellowships

November 27, 2024

Zongyu Li and Ji Seul Han have received ACS and ADA fellowships

Proposed model for role of CNA cells during tumorigenesis

Brugge lab and collaborators use single-cell approaches to identify early cancer-like alterations in normal and high-risk breast epithelial cells

November 25, 2024

Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations

Headshot of Matt Baird and Samantha Sedor

Finley and Shao Lab graduate students successfully defend dissertations

November 20, 2024

Matthew Baird and Samantha Sedor successfully defended their dissertations recently.

Mrc1 acts as a parental histone distribution site

Moazed Lab Discovers a New Mechanism for Parental Histone Recycling and Epigenetic Inheritance

November 19, 2024

A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance

New mechanistic model for BRCA1 hereditary breast cancer

Brugge Lab found new insights into hereditary cancer risk

November 15, 2024

Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer.

anti-diabetic small molecules targeting selective protein lysine acetylation

Puigserver lab maps novel anti-diabetic metabolic routes that re-direct lactate and gluconeogenic carbon substrates to mitochondrial oxidation

November 8, 2024

Design of anti-diabetic small molecules targeting selective protein lysine acetylation that inhibit liver glucose production through complete lactate oxidation

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