Spyros Artavanis-Tsakonas has been awarded the 23rd annual Wiley Prize in Biomedical Sciences for discovering the genes and novel biochemical mechanism of Notch signaling, which controls myriad cell fate decisions in metazoans.

"Notch signaling involves unique biochemical steps and is used by animals to allow one cell to determine the fate of its neighbors. The Wiley Jury recognizes this important signaling pathway for its distinctive features and its critical role in human health and disease," said Dr. Titia de Lange of Rockefeller University, Chairperson of the Wiley Prize awards jury.

“The Wiley Foundation honors scientists who are dedicated to solving complex biological mechanisms which result in seminal discoveries that open the door for future innovations,” said Deborah Wiley, Chair of the Wiley Foundation. “The work of the 23^rd Annual Wiley Prize recipients truly upholds this mission by laying the foundation for core genetic and regulatory framework of the Notch signaling system, which unravels the fundamentals of normal and disease development and has fueled research into medicine for new treatments.”

First awarded in 2002, the Wiley Prize in Biomedical Sciences is presented annually to recognize contributions that have opened new fields of research or have advanced concepts in a particular biomedical discipline. Among the many distinguished recipients of the Wiley Prize in Biomedical Sciences, thirteen have gone on to be awarded the Nobel Prize in Physiology or Medicine and five have been awarded the Nobel Prize in Chemistry.

Wiley (2.28.2025) The 23rd Annual Wiley Prize in Biomedical Sciences Awarded for Research in Notch Signaling [Press Release]