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News

Lawrence Kazak headshot

Lawrence Kazak named ASCB's 2017 Bernfield Memorial Award winner!

October 24, 2017

Congratulations to Dr. Lawrence Kazak, a postdoctoral fellow in the Spiegelman lab, who was recently awarded the American Society for Cell Biology's 2017 Merton Bernfield Memorial Award.

Healthy cell and tumor cell diagram

Haigis lab reveals metabolic recycling is a crucial source of breast cancer biomass

October 19, 2017

Cancer cells increase nutrient consumption and metabolic fitness to support rapid growth and proliferation.

Graphic of Baseline, PI3k/mTOR therapy and PI3K/mTOR & apoptotic therapy cells

New study by Brugge lab uncovers apoptotic vulnerabilities in ovarian cancer

September 22, 2017

High-grade serous ovarian cancers (HGS-OvCa) frequently develop chemotherapy resistance; therefore, identification of novel therapies for the treatment of chemotherapy-resistant tumors remains an unmet need. 

Bob Farese headshot

Bob Farese announced as a 2018 Laureate Award winner by the Endocrine Society

September 14, 2017

Bob Farese has been selected as one of 14 leaders in the endocrinology field to receive a prestigious 2018 Laureate Award from the Endocrine Society. 

LPS graphic

Liao lab uncovers the structural basis for LPS transport by ABC transporter MsbA

September 8, 2017

Lipopolysaccharide (LPS, also known as endotoxin) in Gram-negative bacteria is critical for the bacterial survival and their resistance to antibiotics. 

Diagram showing mutation of Ube20 gene

Finley lab discovers how red blood cells remodel during terminal differentiation

August 24, 2017

The Finley lab, in a recent publication in Science, found that a mutation in the murine Ube2o gene, which encodes an ubiquitin-conjugating enzyme induced during erythropoiesis, results in anemia. 

Graphic of Motility of Straight Tubulin and Depolymerase of Curved Tubulin

Depolymerase mechanism for a length-dependent microtubule regulator defined by Pellman lab

August 23, 2017

Proper establishment of the size of intracellular microtubule-based structures, the mitotic spindle or the cilia, is key for their cellular function.

Images of Basal Lipolysis, Stimulated Lipolysis, and DGAT1 inhibition during Stimulated Liplysis

Farese and Walther lab discovers triglyceride synthesis enzyme DGAT1 protects adipocytes from lipid induced ER stress during lipolysis

August 10, 2017

Triglyceride (TG) storage in adipose tissue provides the major reservoir for metabolic energy in mammals.

Adrian Salic headshot

Recent Faculty Promotion: Adrian Salic

July 21, 2017

Congratulations to Adrian Salic on his promotion to Professor of Cell Biology!

Graphic of Hrd1 and Hrd3

Rapoport and Liao labs determine the cryo-EM structure of the ERAD Hrd1/Hrd3 complex

July 19, 2017

A conserved pathway called “endoplasmic reticulum associated protein degradation (ERAD) is responsible for the disposal of misfolded ER proteins. 

Near-atomic resolution snapshots of CRISPR

Liao lab discovers key steps in CRISPR’s mechanism of action

July 6, 2017

Scientists in the Liao lab and Cornell University have produced near-atomic resolution snapshots of CRISPR that reveal key steps in its mechanism of action. 

Errors in RNA splicing

New study by Reed lab reveals how RNA splicing errors may cause the development of ALS and a specific form of dementia

June 13, 2017

The most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) may stem from errors in RNA splicing, an intermediary and critical step for translating genetic instructions into functional proteins.

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