High-grade serous ovarian cancers (HGS-OvCa) frequently develop chemotherapy resistance; therefore, identification of novel therapies for the treatment of chemotherapy-resistant tumors remains an unmet need.
Lipopolysaccharide (LPS, also known as endotoxin) in Gram-negative bacteria is critical for the bacterial survival and their resistance to antibiotics.
The Finley lab, in a recent publication in Science, found that a mutation in the murine Ube2o gene, which encodes an ubiquitin-conjugating enzyme induced during erythropoiesis, results in anemia.
Scientists in the Liao lab and Cornell University have produced near-atomic resolution snapshots of CRISPR that reveal key steps in its mechanism of action.
The most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) may stem from errors in RNA splicing, an intermediary and critical step for translating genetic instructions into functional proteins.
The most recent project from the Harper & Gygi labs, BioPlex 2.0 (Biophysical Interactions of ORFeome-derived complexes), was featured in Nature and uses affinity purification-mass spectrometry to elucidate protein interaction networks and co-complexes nucleated by more than 25% of protein-coding genes from the human genome.
