Type I CRISPR-Cas system features a sequential target-searching and degradation process on double-stranded DNA by the RNA-guided Cascade (CRISPR associated complex for antiviral defense) complex and the nuclease-helicase fusion enzyme Cas3, respectively.
The Chouchani lab has found in their most recent Nature paper that the anti-obesity properties of thermogenic adipose tissues can be activated by the mitochondrial metabolite succinate.
The Brugge lab has shown that the calcium channel protein, TRPA1, aids in tumor survival and has proposed targeting this protein as a potential cancer treatment.
Alban Ordureau, a postdoc in the Harper lab, has developed a proteomics method that allows for the dynamics of PARKIN-dependent mitochondrial ubiquitylation to be followed with unprecedented preision and in a site-specific manner.
Dr. Yang Shi, Merton Bernfield Professor of Neonatology at Boston Children's Hospital and Professor of Cell Biology at HMS, was appointed the C.H. Waddington Professor of Pediatrics, effective January 1, 2018.
The Kirchhausen lab, in collaboration with Nobel laureate and Janelia group leader Eric Betzig, has developed a microscope capable of capturing 3-D images and videos of cells inside living organisms in unprecedented detail.
Dr. Wade Harper, Chair of Cell Biology and the Bert and Natalie Vallee Professor of Molecular Pathology, was just named a 2018 Fellow of the American Academy of Arts and Sciences.
Nick Bodnar, an MD/PhD student from the Rapoport lab, was one of 13 graduate students selected to receive a 2018 Harold M. Weintraub Graduate Student Award, which recognizes outstanding achievement in graduate studies in the biological sciences.
