Assistant Professor Sichen (Susan) Shao was announced as one of 22 early-career scientists and engineers in the 2019 class of Packard Fellows for Science and Engineering from the David and Lucile Packard Foundation.
In their recent study published in Cell Reports, the Haigis Lab identified extracellular alanine as one of the extracellular nutrients required to support T cell activation.
Structural analyses, functional characterizations and computational studies reveal the ion-translocation pathway, ion-binding sites and key residues for transport activity.
This study reveals the assembly principles of a thermostable T=4 shell topology and its catalytic ferroxidase cargo and show interactions underlying cargo-shell co-assembly.
In their study in NSMB, the Shao Lab identified a mechanism that coordinates tRNA and protein quality control, in which a dedicated factor specifically cleaves off the invariant 3’-CCA from peptidyl-tRNA on stalled ribosomal complexes.
