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News

Yang Shi headshot

Yang Shi elected to the American Academy of Arts and Sciences, 2016 Class

April 27, 2016

We congratulate faculty member Yang Shi, one of four members of the Harvard Medical School community who are part of this year’s class of national and international leaders elected to the American Academy of Arts and Sciences.

Crystal structure of active protein translocation channel

Rapoport lab determines structure of the active translocon

March 23, 2016

A recent paper by Li et al. (Rapoport lab, with help from Hidde Ploegh’s lab at the MIT), reports a crystal structure of the active protein translocation channel, which had been a “holy grail” in the field. 

Diagram of Beneficial effects of circulating Slit2-C

Spiegelman Lab identifies Slit2-C as secreted protein that regulates adipose tissue thermogenesis

February 24, 2016

This new work, by Katrin Svensson in the Spiegelman Lab and recently published in Cell Metabolism, has found a new function for Slit2, a protein secreted from beige cells. 

Diagram of different stages of cells

Rapoport Lab clarifies mechanism of a bacterial O-glycosyltransferase

February 24, 2016

Many proteins are glycosylated on Ser or Thr residues, but the mechanism of O-glycosylation is only poorly understood.

Graphic of genes

Liao Lab determines high-resolution cryo-EM structures of synaptic RAG1-RAG2 complex to reveal the molecular mechanism of V(D)J recombination

February 24, 2016

Diverse repertoires of antigen-receptor genes that result from combinatorial splicing of V(D)J gene segments are hallmarks of vertebrate immunity. 

Anders Näär headshot

Näär Lab identifies compound that prevents multidrug-resistant fungi from pumping out drugs

February 22, 2016

An international team led by researchers at Harvard Medical School and Massachusetts General Hospital has devised a new way to approach the problem of multidrug-resistant fungal infections that can be life-threatening to people with weakened immune systems. 

Anders Näär headshot

Anders Näär receives Research to Prevent Blindness Stein Innovation Award

December 9, 2015

RPB Stein Innovation Awards provide funds to researchers in the ophthalmology department and to basic science or other relevant vision researchers outside of the ophthalmology department (but within the institution) with a common goal of understanding the visual system and the diseases that compromise its function.

Graphic showing respiratory chain and ATP synthase

New pathway of energy expenditure from the Spiegelman Lab

October 29, 2015

The epidemic of obesity and diabetes have increased interest in pathways that cause an increase in metabolic rates.

Ferritin residue involved in NCOA4 binding

Harper Lab elucidates the molecular underpinnings of delivery of ferritin to autophagosomes through the NCOA4 pathway and demonstrates a role for NCOA4 in erythroid development

October 7, 2015

NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical for regulation of intracellular iron bioavailability. 

Diagram of AAA-ATPase VCP network

Through a systematic proteomic analysis of the VCP–UBXD adaptor network, the Harper Lab identifies a role for UBXN10 in regulating ciliogenesis

October 7, 2015

The AAA-ATPase VCP (also known as p97 or CDC48) uses ATP hydrolysis to ‘segregate’ ubiquitylated proteins from their binding partners, and has been implicated in numerous pathways ranging from ERAD to repair of damaged DNA.

Graphic of Pex6 and Pex1

Collaboration results in structure of the Pex1/Pex6 ATPase

July 23, 2015

The Pex1 and Pex6 ATPases participate in peroxisome biogenesis. 

Malcom Whitman headshot

Malcolm Whitman's research on halofuginone licensed to Allied-Bristol Life Sciences

July 7, 2015

Allied-Bristol Life Sciences, a joint venture between the university commercialization specialist Allied Minds and the US pharmaceutical company Bristol-Myers Squibb, is licensing research carried out by Malcolm Whitman on halofuginone, an active ingredient in blue evergreen hydrangea root.

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