Structural analyses, functional characterizations and computational studies reveal the ion-translocation pathway, ion-binding sites and key residues for transport activity.
This study reveals the assembly principles of a thermostable T=4 shell topology and its catalytic ferroxidase cargo and show interactions underlying cargo-shell co-assembly.
In their study in NSMB, the Shao Lab identified a mechanism that coordinates tRNA and protein quality control, in which a dedicated factor specifically cleaves off the invariant 3’-CCA from peptidyl-tRNA on stalled ribosomal complexes.
Gram-negative bacteria are among the most difficult pathogen to combat, mainly due to their unique “outer membrane” which prevents most antibiotics from entering the cell.
