The cellular activities of ribosomes, the molecular machines that synthesize proteins, regulate gene expression during many physiological processes such as blood cell differentiation.
The Yuan Lab has discovered a molecular link between aging and two major neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Type I CRISPR-Cas system features a sequential target-searching and degradation process on double-stranded DNA by the RNA-guided Cascade (CRISPR associated complex for antiviral defense) complex and the nuclease-helicase fusion enzyme Cas3, respectively.
The Chouchani lab has found in their most recent Nature paper that the anti-obesity properties of thermogenic adipose tissues can be activated by the mitochondrial metabolite succinate.
The Brugge lab has shown that the calcium channel protein, TRPA1, aids in tumor survival and has proposed targeting this protein as a potential cancer treatment.
Alban Ordureau, a postdoc in the Harper lab, has developed a proteomics method that allows for the dynamics of PARKIN-dependent mitochondrial ubiquitylation to be followed with unprecedented preision and in a site-specific manner.
