Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas, Ph.D.

Professor of Cell Biology, Emeritus (HMS)
Professeur au Collège de France

Spyros Artavanis-Tsakonas, Ph.D., is Professor Emeritus of Cell Biology but continues to maintain a research group. He received his doctoral degree at Cambridge University, England and pursued postdoctoral research at the University of Basel, Switzerland, and Stanford University. He has been a faculty member at Harvard Medical School's Cell Biology department since 1998, and was Chief Scientific Officer at Biogen from 2012 until 2016.

Using molecular and genetic approaches, the Artavanis-Tsakonas lab is examining how various signals are integrated in undifferentiated cells in order to dictate cell fates. Our main experimental system is Drosophila and are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies with the current focus on neurodegeneration.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301C

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7107

Alterations in Notch signaling in neoplastic lesions of the human cervix.
Authors: Authors: Zagouras P, Stifani S, Blaumueller CM, Carcangiu ML, Artavanis-Tsakonas S.
Proc Natl Acad Sci U S A
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The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae.
Authors: Authors: Dawson IA, Roth S, Artavanis-Tsakonas S.
J Cell Biol
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Notch signaling.
Authors: Authors: Artavanis-Tsakonas S, Matsuno K, Fortini ME.
Science
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The suppressor of hairless protein participates in notch receptor signaling.
Authors: Authors: Fortini ME, Artavanis-Tsakonas S.
Cell
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Modulation of wingless signaling by Notch in Drosophila.
Authors: Authors: Hing HK, Sun X, Artavanis-Tsakonas S.
Mech Dev
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The molecular cloning and characterization of Drosophila melanogaster myosin-IA and myosin-IB.
Authors: Authors: Morgan NS, Skovronsky DM, Artavanis-Tsakonas S, Mooseker MS.
J Mol Biol
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Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway.
Authors: Authors: Diederich RJ, Matsuno K, Hing H, Artavanis-Tsakonas S.
Development
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A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene.
Authors: Authors: Fehon RG, Dawson IA, Artavanis-Tsakonas S.
Development
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A member of the Notch group of interacting loci, deltex encodes a cytoplasmic basic protein.
Authors: Authors: Busseau I, Diederich RJ, Xu T, Artavanis-Tsakonas S.
Genetics
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Identification of a divergent actin-related protein in Drosophila.
Authors: Authors: Frankel S, Heintzelman MB, Artavanis-Tsakonas S, Mooseker MS.
J Mol Biol
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