Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas, Ph.D.

Professor of Cell Biology, Emeritus (HMS)
Professeur au Collège de France

Spyros Artavanis-Tsakonas, Ph.D., is Professor Emeritus of Cell Biology but continues to maintain a research group. He received his doctoral degree at Cambridge University, England and pursued postdoctoral research at the University of Basel, Switzerland, and Stanford University. He has been a faculty member at Harvard Medical School's Cell Biology department since 1998, and was Chief Scientific Officer at Biogen from 2012 until 2016.

Using molecular and genetic approaches, the Artavanis-Tsakonas lab is examining how various signals are integrated in undifferentiated cells in order to dictate cell fates. Our main experimental system is Drosophila and are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies with the current focus on neurodegeneration.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301C

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7107

Notch: neurogenesis is only part of the picture.
Authors: Authors: Fortini ME, Artavanis-Tsakonas S.
Cell
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An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye.
Authors: Authors: Fortini ME, Rebay I, Caron LA, Artavanis-Tsakonas S.
Nature
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Analysis of phenotypic abnormalities and cell fate changes caused by dominant activated and dominant negative forms of the Notch receptor in Drosophila development.
Authors: Authors: Rebay I, Fortini ME, Artavanis-Tsakonas S.
C R Acad Sci III
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Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.
Authors: Authors: Rebay I, Fehon RG, Artavanis-Tsakonas S.
Cell
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Cloning of a secretory gelsolin from Drosophila melanogaster.
Authors: Authors: Heintzelman MB, Frankel SA, Artavanis-Tsakonas S, Mooseker MS.
J Mol Biol
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Mutations of the fizzy locus cause metaphase arrest in Drosophila melanogaster embryos.
Authors: Authors: Dawson IA, Roth S, Akam M, Artavanis-Tsakonas S.
Development
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Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.
Authors: Authors: Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S.
Nat Genet
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Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.
Authors: Authors: Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S.
Nat Genet
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Modularity of the slit protein. Characterization of a conserved carboxy-terminal sequence in secreted proteins and a motif implicated in extracellular protein interactions.
Authors: Authors: Rothberg JM, Artavanis-Tsakonas S.
J Mol Biol
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The Enhancer of split [E(spl)] locus of Drosophila encodes seven independent helix-loop-helix proteins.
Authors: Authors: Delidakis C, Artavanis-Tsakonas S.
Proc Natl Acad Sci U S A
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