Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas, Ph.D.

Professor of Cell Biology, Emeritus (HMS)
Professeur au Collège de France

Spyros Artavanis-Tsakonas, Ph.D., is Professor Emeritus of Cell Biology but continues to maintain a research group. He received his doctoral degree at Cambridge University, England and pursued postdoctoral research at the University of Basel, Switzerland, and Stanford University. He has been a faculty member at Harvard Medical School's Cell Biology department since 1998, and was Chief Scientific Officer at Biogen from 2012 until 2016.

Using molecular and genetic approaches, the Artavanis-Tsakonas lab is examining how various signals are integrated in undifferentiated cells in order to dictate cell fates. Our main experimental system is Drosophila and are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies with the current focus on neurodegeneration.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301C

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7107

An actin-related protein in Drosophila colocalizes with heterochromatin protein 1 in pericentric heterochromatin.
Authors: Authors: Frankel S, Sigel EA, Craig C, Elgin SC, Mooseker MS, Artavanis-Tsakonas S.
J Cell Sci
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Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane.
Authors: Authors: Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S.
Cell
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Alagille syndrome--a notch up for the Notch receptor.
Authors: Authors: Artavanis-Tsakonas S.
Nat Genet
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Comparative aspects of Notch signaling in lower and higher eukaryotes.
Authors: Authors: Blaumueller CM, Artavanis-Tsakonas S.
Perspect Dev Neurobiol
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Analysis of dominant enhancers and suppressors of activated Notch in Drosophila.
Authors: Authors: Verheyen EM, Purcell KJ, Fortini ME, Artavanis-Tsakonas S.
Genetics
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The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands.
Authors: Authors: Sun X, Artavanis-Tsakonas S.
Development
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Interaction between Wingless and Notch signaling pathways mediated by dishevelled.
Authors: Authors: Axelrod JD, Matsuno K, Artavanis-Tsakonas S, Perrimon N.
Science
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Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia.
Authors: Authors: Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S.
Genomics
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Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells.
Authors: Authors: Ahmad I, Zaqouras P, Artavanis-Tsakonas S.
Mech Dev
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Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats.
Authors: Authors: Matsuno K, Diederich RJ, Go MJ, Blaumueller CM, Artavanis-Tsakonas S.
Development
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