Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas, Ph.D.

Professor of Cell Biology, Emeritus (HMS)
Professeur au Collège de France

Spyros Artavanis-Tsakonas, Ph.D., is Professor Emeritus of Cell Biology but continues to maintain a research group. He received his doctoral degree at Cambridge University, England and pursued postdoctoral research at the University of Basel, Switzerland, and Stanford University. He has been a faculty member at Harvard Medical School's Cell Biology department since 1998, and was Chief Scientific Officer at Biogen from 2012 until 2016.

Using molecular and genetic approaches, the Artavanis-Tsakonas lab is examining how various signals are integrated in undifferentiated cells in order to dictate cell fates. Our main experimental system is Drosophila and are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies with the current focus on neurodegeneration.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301C

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7107

Delta Cleavage Products and Methods Based Thereon
Authors: Authors: Artavanis-Tsakonas et al
2000.
1997.
Authors: Authors: Human Notch and Delta, Binding Domains in Toporythmic Proteins, and Methods Based Thereon

1993.
Authors: Authors: Nucleotide and Protein Sequences on the Serrate Gene and Methods Based Thereon

Manipulation of Non-Terminally Differentiated Cells Using the Notch Pathway
Authors: Authors: Artavanis-Tsakonas et al.


2000.
Nat Gent
Authors: Authors: Human Alagille Syndrome- a notch up for the Notch Receptor
1997; 16:212-13.
Developmental Genetics
Authors: Authors: The Notch locus of Drosophila melanogaster: A molecular analysis
1984; 4:223-254.
Nucleotide and Protein Sequences of the Vertebrate Serrate Gene and Methods Based Thereon
Authors: Authors: Artavanis-Tsakonas et al
1999.
Antibodies to Human Notch Proteins and Fragments
Authors: Authors: Artavanis-Tsakonas et al
2000.
Nucleotide and Protein Sequences of the Serrate Gene and Methods Based Thereon
Authors: Authors: Artavanis-Tsakonas et al
1999.
1975.
Authors: Authors: Triose phosphate isomerase from Bacillus stearothermophilus