Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas, Ph.D.

Professor of Cell Biology, Emeritus (HMS)
Professeur au Collège de France

Spyros Artavanis-Tsakonas, Ph.D., is Professor Emeritus of Cell Biology but continues to maintain a research group. He received his doctoral degree at Cambridge University, England and pursued postdoctoral research at the University of Basel, Switzerland, and Stanford University. He has been a faculty member at Harvard Medical School's Cell Biology department since 1998, and was Chief Scientific Officer at Biogen from 2012 until 2016.

Using molecular and genetic approaches, the Artavanis-Tsakonas lab is examining how various signals are integrated in undifferentiated cells in order to dictate cell fates. Our main experimental system is Drosophila and are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies with the current focus on neurodegeneration.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301C

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7107

Activated Forms of Notch and Methods Based Thereon
Authors: Authors: Artavanis-Tsakonas et al
1999.
1996.
Authors: Authors: Nucleotide and Protein Sequences on the Vertebrate Serrate Gene and Methods Based Thereon

Proc Natl Acad Sci U S A
Authors: Authors: The Enhancer of split locus of Drosophila harbors seven independent HLH proteins
1992; 89:8731-5.
Proc Natl Acad Sci U S A
Authors: Authors: The molecular cloning of Notch: a locus affecting neurogenesis in Drosophila
1983; 80:1977-81.
Nucleotide and Protein Sequences of the Vertebrate Delta Genes and Methods Based Thereon
Authors: Authors: Artavanis-Tsakonas et al
2001.
1997.
Authors: Authors: Vertebrate Deltex Proteins, Nucleic Acids and Antibodies, and Related Methods and Compositions

Therapeutic and Diagnostic Methods and Compositions Based on Notch Proteins and Nucleic Acids
Authors: Authors: Artavanis-Tsakonas et al
1998.
Serrate Fragments and Derivatives
Authors: Authors: Artavanis-Tsakonas

1999.
1998.
Authors: Authors: Deltex Proteins

1994.
Authors: Authors: Therapeutic and Diagnostic Methods and Compositions Based on Notch Proteins and Nucleic Acids