Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas, Ph.D.

Professor of Cell Biology, Emeritus (HMS)
Professeur au Collège de France

Spyros Artavanis-Tsakonas, Ph.D., is Professor Emeritus of Cell Biology but continues to maintain a research group. He received his doctoral degree at Cambridge University, England and pursued postdoctoral research at the University of Basel, Switzerland, and Stanford University. He has been a faculty member at Harvard Medical School's Cell Biology department since 1998, and was Chief Scientific Officer at Biogen from 2012 until 2016.

Using molecular and genetic approaches, the Artavanis-Tsakonas lab is examining how various signals are integrated in undifferentiated cells in order to dictate cell fates. Our main experimental system is Drosophila and are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies with the current focus on neurodegeneration.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301C

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7107

The molecular genetics of Enhancer of split, a gene required for embryonic neural development in Drosophila.
Authors: Authors: Preiss A, Hartley DA, Artavanis-Tsakonas S.
EMBO J
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The molecular biology of the Notch locus and the fine tuning of differentiation in Drosophila.
Authors: Authors: Artavanis-Tsakonas S.
Trends Genet
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The embryonic expression of the Notch locus of Drosophila melanogaster and the implications of point mutations in the extracellular EGF-like domain of the predicted protein.
Authors: Authors: Hartley DA, Xu TA, Artavanis-Tsakonas S.
EMBO J
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Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats.
Authors: Authors: Wharton KA, Johansen KM, Xu T, Artavanis-Tsakonas S.
Cell
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The molecular genetics of the Notch locus in Drosophila melanogaster.
Authors: Authors: Grimwade BG, Muskavitch MA, Welshons WJ, Yedvobnick B, Artavanis-Tsakonas S.
Dev Biol
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Molecular genetics of Drosophila neurogenesis.
Authors: Authors: Yedvobnick B, Muskavitch MA, Wharton KA, Halpern ME, Paul E, Grimwade BG, Artavanis-Tsakonas S.
Cold Spring Harb Symp Quant Biol
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opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster.
Authors: Authors: Wharton KA, Yedvobnick B, Finnerty VG, Artavanis-Tsakonas S.
Cell
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Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster.
Authors: Authors: Artavanis-Tsakonas S, Muskavitch MA, Yedvobnick B.
Proc Natl Acad Sci U S A
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DNA sequences flanking the starts of the hsp 70 and alpha beta heat shock genes are homologous.
Authors: Authors: Lis J, Neckameyer W, Mirault ME, Artavanis-Tsakonas S, Lall P, Martin G, Schedl P.
Dev Biol
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Transfer RNA genes of Drosophila melanogaster.
Authors: Authors: Dudler R, Egg AH, Kubli E, Artavanis-Tsakonas S, Gehring WJ, Steward R, Schedl P.
Nucleic Acids Res
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