Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas, Ph.D.

Professor of Cell Biology, Emeritus (HMS)
Professeur au Collège de France

Spyros Artavanis-Tsakonas, Ph.D., is Professor Emeritus of Cell Biology but continues to maintain a research group. He received his doctoral degree at Cambridge University, England and pursued postdoctoral research at the University of Basel, Switzerland, and Stanford University. He has been a faculty member at Harvard Medical School's Cell Biology department since 1998, and was Chief Scientific Officer at Biogen from 2012 until 2016.

Using molecular and genetic approaches, the Artavanis-Tsakonas lab is examining how various signals are integrated in undifferentiated cells in order to dictate cell fates. Our main experimental system is Drosophila and are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies with the current focus on neurodegeneration.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301C

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7107

Notch and the molecular genetics of neuroblast segregation in Drosophila.
Authors: Authors: Artavanis-Tsakonas S, Delidakis C, Fehon R, Hartley D, Herndon V, Johansen K, Markopoulou K, Preiss A, Rebay I, Scottgale N, et al.
Mol Reprod Dev
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Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila.
Authors: Authors: Fehon RG, Kooh PJ, Rebay I, Regan CL, Xu T, Muskavitch MA, Artavanis-Tsakonas S.
Cell
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The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis.
Authors: Authors: Xu T, Rebay I, Fleming RJ, Scottgale TN, Artavanis-Tsakonas S.
Genes Dev
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Genes Dev
Authors: Authors: The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster
4: 2188-201
The notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development.
Authors: Authors: Johansen KM, Fehon RG, Artavanis-Tsakonas S.
J Cell Biol
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Physical and functional definition of the Drosophila Notch locus by P element transformation.
Authors: Authors: Ramos RG, Grimwade BG, Wharton KA, Scottgale TN, Artavanis-Tsakonas S.
Genetics
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The expression of the neurogenic locus Notch during the postembryonic development of Drosophila melanogaster and its relationship to mitotic activity.
Authors: Authors: Markopoulou K, Artavanis-Tsakonas S.
J Neurogenet
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Phenotypic and molecular analysis of the facets, a group of intronic mutations at the Notch locus of Drosophila melanogaster which affect postembryonic development.
Authors: Authors: Markopoulou K, Welshons WJ, Artavanis-Tsakonas S.
Genetics
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slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system.
Authors: Authors: Rothberg JM, Hartley DA, Walther Z, Artavanis-Tsakonas S.
Cell
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A deduced gene product from the Drosophila neurogenic locus, enhancer of split, shows homology to mammalian G-protein beta subunit.
Authors: Authors: Hartley DA, Preiss A, Artavanis-Tsakonas S.
Cell
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