Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas, Ph.D.

Professor of Cell Biology, Emeritus (HMS)
Professeur au Collège de France

Spyros Artavanis-Tsakonas, Ph.D., is Professor Emeritus of Cell Biology but continues to maintain a research group. He received his doctoral degree at Cambridge University, England and pursued postdoctoral research at the University of Basel, Switzerland, and Stanford University. He has been a faculty member at Harvard Medical School's Cell Biology department since 1998, and was Chief Scientific Officer at Biogen from 2012 until 2016.

Using molecular and genetic approaches, the Artavanis-Tsakonas lab is examining how various signals are integrated in undifferentiated cells in order to dictate cell fates. Our main experimental system is Drosophila and are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies with the current focus on neurodegeneration.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301C

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7107

The involvement of the Notch locus in Drosophila oogenesis.
Authors: Authors: Xu T, Caron LA, Fehon RG, Artavanis-Tsakonas S.
Development
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Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor.
Authors: Authors: Rebay I, Fleming RJ, Fehon RG, Cherbas L, Cherbas P, Artavanis-Tsakonas S.
Cell
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Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster.
Authors: Authors: Delidakis C, Preiss A, Hartley DA, Artavanis-Tsakonas S.
Genetics
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Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function.
Authors: Authors: Fehon RG, Johansen K, Rebay I, Artavanis-Tsakonas S.
J Cell Biol
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Developmental analysis of the facets, a group of intronic mutations at the Notch locus of Drosophila melanogaster that affect postembryonic development.
Authors: Authors: Markopoulou K, Artavanis-Tsakonas S.
J Exp Zool
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The Notch locus and the cell biology of neuroblast segregation.
Authors: Authors: Artavanis-Tsakonas S, Delidakis C, Fehon RG.
Annu Rev Cell Biol
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Choosing a cell fate: a view from the Notch locus.
Authors: Authors: Artavanis-Tsakonas S, Simpson P.
Trends Genet
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The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster.
Authors: Authors: Fleming RJ, Scottgale TN, Diederich RJ, Artavanis-Tsakonas S.
Genes Dev
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slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.
Authors: Authors: Rothberg JM, Jacobs JR, Goodman CS, Artavanis-Tsakonas S.
Genes Dev
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deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster.
Authors: Authors: Xu T, Artavanis-Tsakonas S.
Genetics
View full abstract on Pubmed