Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas, Ph.D.

Professor of Cell Biology, Emeritus (HMS)
Professeur au Collège de France

Spyros Artavanis-Tsakonas, Ph.D., is Professor Emeritus of Cell Biology but continues to maintain a research group. He received his doctoral degree at Cambridge University, England and pursued postdoctoral research at the University of Basel, Switzerland, and Stanford University. He has been a faculty member at Harvard Medical School's Cell Biology department since 1998, and was Chief Scientific Officer at Biogen from 2012 until 2016.

Using molecular and genetic approaches, the Artavanis-Tsakonas lab is examining how various signals are integrated in undifferentiated cells in order to dictate cell fates. Our main experimental system is Drosophila and are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies with the current focus on neurodegeneration.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301C

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7107

Lab fax: 617-432-7050

Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila.
Authors: Authors: Pallavi SK, Ho DM, Hicks C, Miele L, Artavanis-Tsakonas S.
EMBO J
View full abstract on Pubmed
Notch and disease: a growing field.
Authors: Authors: Louvi A, Artavanis-Tsakonas S.
Semin Cell Dev Biol
View full abstract on Pubmed
Drosophila protein interaction map (DPiM): a paradigm for metazoan protein complex interactions.
Authors: Authors: Guruharsha KG, Obar RA, Mintseris J, Aishwarya K, Krishnan RT, Vijayraghavan K, Artavanis-Tsakonas S.
Fly (Austin)
View full abstract on Pubmed
Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal.
Authors: Authors: Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S.
J Cell Biol
View full abstract on Pubmed
A protein complex network of Drosophila melanogaster.
Authors: Authors: Guruharsha KG, Rual JF, Zhai B, Mintseris J, Vaidya P, Vaidya N, Beekman C, Wong C, Rhee DY, Cenaj O, McKillip E, Shah S, Stapleton M, Wan KH, Yu C, Parsa B, Carlson JW, Chen X, Kapadia B, VijayRaghavan K, Gygi SP, Celniker SE, Obar RA, Artavanis-Tsakonas S.
Cell
View full abstract on Pubmed
Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease.
Authors: Authors: Arboleda-Velasquez JF, Manent J, Lee JH, Tikka S, Ospina C, Vanderburg CR, Frosch MP, Rodríguez-Falcón M, Villen J, Gygi S, Lopera F, Kalimo H, Moskowitz MA, Ayata C, Louvi A, Artavanis-Tsakonas S.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Trp53 regulates Notch 4 signaling through Mdm2.
Authors: Authors: Sun Y, Klauzinska M, Lake RJ, Lee JM, Santopietro S, Raafat A, Salomon D, Callahan R, Artavanis-Tsakonas S.
J Cell Sci
View full abstract on Pubmed
Modeling spinal muscular atrophy in Drosophila links Smn to FGF signaling.
Authors: Authors: Sen A, Yokokura T, Kankel MW, Dimlich DN, Manent J, Sanyal S, Artavanis-Tsakonas S.
J Cell Biol
View full abstract on Pubmed
Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice.
Authors: Authors: Fre S, Hannezo E, Sale S, Huyghe M, Lafkas D, Kissel H, Louvi A, Greve J, Louvard D, Artavanis-Tsakonas S.
PLoS One
View full abstract on Pubmed
Conserved genes act as modifiers of invertebrate SMN loss of function defects.
Authors: Authors: Dimitriadi M, Sleigh JN, Walker A, Chang HC, Sen A, Kalloo G, Harris J, Barsby T, Walsh MB, Satterlee JS, Li C, Van Vactor D, Artavanis-Tsakonas S, Hart AC.
PLoS Genet
View full abstract on Pubmed