Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas, Ph.D.

Professor of Cell Biology, Emeritus (HMS)
Professeur au Collège de France

Spyros Artavanis-Tsakonas, Ph.D., is Professor Emeritus of Cell Biology but continues to maintain a research group. He received his doctoral degree at Cambridge University, England and pursued postdoctoral research at the University of Basel, Switzerland, and Stanford University. He has been a faculty member at Harvard Medical School's Cell Biology department since 1998, and was Chief Scientific Officer at Biogen from 2012 until 2016.

Using molecular and genetic approaches, the Artavanis-Tsakonas lab is examining how various signals are integrated in undifferentiated cells in order to dictate cell fates. Our main experimental system is Drosophila and are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies with the current focus on neurodegeneration.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301C

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7107

Lab fax: 617-432-7050

Molecular structure and dimeric organization of the Notch extracellular domain as revealed by electron microscopy.
Authors: Authors: Kelly DF, Lake RJ, Middelkoop TC, Fan HY, Artavanis-Tsakonas S, Walz T.
PLoS One
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Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.
Authors: Authors: Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, Pandya D, Lu Y, Mills GB, Aster JC, Artavanis-Tsakonas S, Brugge JS.
Proc Natl Acad Sci U S A
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Notch: the past, the present, and the future.
Authors: Authors: Artavanis-Tsakonas S, Muskavitch MA.
Curr Top Dev Biol
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In vivo analysis of the Notch receptor S1 cleavage.
Authors: Authors: Lake RJ, Grimm LM, Veraksa A, Banos A, Artavanis-Tsakonas S.
PLoS One
View full abstract on Pubmed
Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine.
Authors: Authors: Fre S, Pallavi SK, Huyghe M, Laé M, Janssen KP, Robine S, Artavanis-Tsakonas S, Louvard D.
Proc Natl Acad Sci U S A
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Nodal points and complexity of Notch-Ras signal integration.
Authors: Authors: Hurlbut GD, Kankel MW, Artavanis-Tsakonas S.
Proc Natl Acad Sci U S A
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Modeling spinal muscular atrophy in Drosophila.
Authors: Authors: Chang HC, Dimlich DN, Yokokura T, Mukherjee A, Kankel MW, Sen A, Sridhar V, Fulga TA, Hart AC, Van Vactor D, Artavanis-Tsakonas S.
PLoS One
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Linking Notch signaling to ischemic stroke.
Authors: Authors: Arboleda-Velasquez JF, Zhou Z, Shin HK, Louvi A, Kim HH, Savitz SI, Liao JK, Salomone S, Ayata C, Moskowitz MA, Artavanis-Tsakonas S.
Proc Natl Acad Sci U S A
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Nanocourses: a short course format as an educational tool in a biological sciences graduate curriculum.
Authors: Authors: Bentley AM, Artavanis-Tsakonas S, Stanford JS.
CBE Life Sci Educ
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Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector.
Authors: Authors: Kankel MW, Hurlbut GD, Upadhyay G, Yajnik V, Yedvobnick B, Artavanis-Tsakonas S.
Genetics
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