Randall King

Randall King, M.D., Ph.D.

Harry C. McKenzie Professor of Cell Biology (HMS)
C-666
617-432-3629
King Lab

Randy King, M.D., Ph.D. was appointed to the faculty in 2000, after three years as the first Institute Fellow of the Institute of Chemistry of Cell Biology at Harvard. He received his undergraduate degree from Carleton College, followed by a Ph.D. in Biochemistry from UCSF, where he co-discovered the Anaphase-Promoting complex/Cyclosome (APC), and M.D. from Harvard Medical School. He was named the Harry C. McKenzie Professor of Cell Biology in 2013 and has received numerous awards in recognition of his contributions to medical education.

The King lab integrates chemical and cell biological approaches to study cell division and chromosome segregation.

Harvard Medical School

Dept. of Cell Biology, C-666

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-4964

A time-series method for automated measurement of changes in mitotic and interphase duration from time-lapse movies.
Authors: Authors: Sigoillot FD, Huckins JF, Li F, Zhou X, Wong ST, King RW.
PLoS One
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Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage.
Authors: Authors: Zeng X, Sigoillot F, Gaur S, Choi S, Pfaff KL, Oh DC, Hathaway N, Dimova N, Cuny GD, King RW.
Cancer Cell
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Enhancement of proteasome activity by a small-molecule inhibitor of USP14.
Authors: Authors: Lee BH, Lee MJ, Park S, Oh DC, Elsasser S, Chen PC, Gartner C, Dimova N, Hanna J, Gygi SP, Wilson SM, King RW, Finley D.
Nature
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Understanding cytokinesis failure.
Authors: Authors: Normand G, King RW.
Adv Exp Med Biol
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When 2+2=5: the origins and fates of aneuploid and tetraploid cells.
Authors: Authors: King RW.
Biochim Biophys Acta
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When 2+2=5: The Origins and Fates of Aneuploid and Tetraploid Cells
Authors: Authors: King, RW
Biochem Biophys Acta Reviews on Cancer
Understanding Cytokinesis Failure
Authors: Authors: Normand G, King RW
Polyploidization and Cancer, Randy Poon, Ed
Novel cell segmentation and online SVM for cell cycle phase identification in automated microscopy.
Authors: Authors: Wang M, Zhou X, Li F, Huckins J, King RW, Wong ST.
Bioinformatics
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Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites.
Authors: Authors: Kleijnen MF, Roelofs J, Park S, Hathaway NA, Glickman M, King RW, Finley D.
Nat Struct Mol Biol
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Distinct sequence elements of cyclin B1 promote localization to chromatin, centrosomes, and kinetochores during mitosis.
Authors: Authors: Bentley AM, Normand G, Hoyt J, King RW.
Mol Biol Cell
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