Randall King

Randall King, M.D., Ph.D.

Harry C. McKenzie Professor of Cell Biology (HMS)
C-666
617-432-3629
King Lab

Randy King, M.D., Ph.D. was appointed to the faculty in 2000, after three years as the first Institute Fellow of the Institute of Chemistry of Cell Biology at Harvard. He received his undergraduate degree from Carleton College, followed by a Ph.D. in Biochemistry from UCSF, where he co-discovered the Anaphase-Promoting complex/Cyclosome (APC), and M.D. from Harvard Medical School. He was named the Harry C. McKenzie Professor of Cell Biology in 2013 and has received numerous awards in recognition of his contributions to medical education.

The King lab integrates chemical and cell biological approaches to study cell division and chromosome segregation.

Harvard Medical School

Dept. of Cell Biology, C-666

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-4964

A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion.
Authors: Authors: Overholtzer M, Mailleux AA, Mouneimne G, Normand G, Schnitt SJ, King RW, Cibas ES, Brugge JS.
Cell
View full abstract on Pubmed
Context based mixture model for cell phase identification in automated fluorescence microscopy
Authors: Authors: Wang M, Zhou X, King RW, Wong ST
BMC Bioinformatics
Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.
Authors: Authors: Crosas B, Hanna J, Kirkpatrick DS, Zhang DP, Tone Y, Hathaway NA, Buecker C, Leggett DS, Schmidt M, King RW, Gygi SP, Finley D.
Cell
View full abstract on Pubmed
Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation.
Authors: Authors: Hanna J, Hathaway NA, Tone Y, Crosas B, Elsasser S, Kirkpatrick DS, Leggett DS, Gygi SP, King RW, Finley D.
Cell
View full abstract on Pubmed
Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology.
Authors: Authors: Kirkpatrick DS, Hathaway NA, Hanna J, Elsasser S, Rush J, Finley D, King RW, Gygi SP.
Nat Cell Biol
View full abstract on Pubmed
Small molecules that delay S phase suppress a zebrafish bmyb mutant.
Authors: Authors: Stern HM, Murphey RD, Shepard JL, Amatruda JF, Straub CT, Pfaff KL, Weber G, Tallarico JA, King RW, Zon LI.
Nat Chem Biol
View full abstract on Pubmed
Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines.
Authors: Authors: Shi Q, King RW.
Nature
View full abstract on Pubmed
Dissecting cell biology with chemical scalpels.
Authors: Authors: Hathaway NA, King RW.
Curr Opin Cell Biol
View full abstract on Pubmed
Adenoviral expression of reporter proteins for high-throughput cell-based screening.
Authors: Authors: Hoyt J, King RW.
Methods Mol Biol
View full abstract on Pubmed
Cytological profiling: providing more haystacks for chemists' needles.
Authors: Authors: Lorang J, King RW.
Genome Biol
View full abstract on Pubmed