Marcia Haigis

Marcia Haigis, Ph.D.

Professor of Cell Biology (HMS)

Marcia C. Haigis, Ph.D. obtained her Ph.D. in Biochemistry from the University of Wisconsin in 2002 and performed postdoctoral studies at MIT studying mitochondrial metabolism. In 2006, Dr. Haigis joined the faculty of Harvard Medical School, where she is currently a Professor in the Department of Cell Biology. Dr. Haigis is an active member of the Paul F. Glenn Center for the Biology of Aging, a member of the Ludwig Center at Harvard Medical School, and was recently selected for the National Academy of Medicine Emerging Leaders in Health and Medicine Program.

The Haigis Lab aims to: 1) identify molecular mechanisms by which mitochondria respond to cellular stress and 2) elucidate how these cellular mechanisms contribute to aging and age-related diseases, such as cancer. The Haigis lab has made key contributions to our understanding of metabolic reprogramming in cancer, including identifying nodes of metabolic vulnerability in the control of fat oxidation in leukemia and metabolic recycling of ammonia to generate amino acids important for tumor growth.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-6865

Regulation of RAS oncogenicity by acetylation.
Authors: Authors: Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM.
Proc Natl Acad Sci U S A
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SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis.
Authors: Authors: Haigis MC, Deng CX, Finley LW, Kim HS, Gius D.
Cancer Res
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Short-term calorie restriction enhances skeletal muscle stem cell function.
Authors: Authors: Cerletti M, Jang YC, Finley LW, Haigis MC, Wagers AJ.
Cell Stem Cell
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Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
Authors: Authors: Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP.
Cell
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Skeletal muscle transcriptional coactivator PGC-1a mediates mitochondrial, but not metabolic, changes during calorie restriction.
Authors: Authors: Finley LW, Lee J, Souza A, Desquiret-Dumas V, Bullock K, Rowe GC, Procaccio V, Clish CB, Arany Z, Haigis MC.
Proc Natl Acad Sci U S A
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Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.
Authors: Authors: De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Maertens O, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, Macleod KF, Cichowski K.
Cancer Cell
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Pancreatic cancers require autophagy for tumor growth.
Authors: Authors: Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC.
Genes Dev
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SIRT3 opposes reprogramming of cancer cell metabolism through HIF1a destabilization.
Authors: Authors: Finley LW, Carracedo A, Lee J, Souza A, Egia A, Zhang J, Teruya-Feldstein J, Moreira PI, Cardoso SM, Clish CB, Pandolfi PP, Haigis MC.
Cancer Cell
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Role of sirtuins and calorie restriction in neuroprotection: implications in Alzheimer's and Parkinson's diseases.
Authors: Authors: Srivastava S, Haigis MC.
Curr Pharm Des
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Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity.
Authors: Authors: Finley LW, Haas W, Desquiret-Dumas V, Wallace DC, Procaccio V, Gygi SP, Haigis MC.
PLoS One
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