Marcia Haigis

Marcia Haigis, Ph.D.

Professor of Cell Biology (HMS)

Marcia C. Haigis, Ph.D. obtained her Ph.D. in Biochemistry from the University of Wisconsin in 2002 and performed postdoctoral studies at MIT studying mitochondrial metabolism. In 2006, Dr. Haigis joined the faculty of Harvard Medical School, where she is currently a Professor in the Department of Cell Biology. Dr. Haigis is an active member of the Paul F. Glenn Center for the Biology of Aging, a member of the Ludwig Center at Harvard Medical School, and was recently selected for the National Academy of Medicine Emerging Leaders in Health and Medicine Program.

The Haigis Lab aims to: 1) identify molecular mechanisms by which mitochondria respond to cellular stress and 2) elucidate how these cellular mechanisms contribute to aging and age-related diseases, such as cancer. The Haigis lab has made key contributions to our understanding of metabolic reprogramming in cancer, including identifying nodes of metabolic vulnerability in the control of fat oxidation in leukemia and metabolic recycling of ammonia to generate amino acids important for tumor growth.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-6865

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.
Authors: Authors: Verdin E, Hirschey MD, Finley LW, Haigis MC.
Trends Biochem Sci
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The aging stress response.
Authors: Authors: Haigis MC, Yankner BA.
Mol Cell
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Sirtuins regulate key aspects of lipid metabolism.
Authors: Authors: Lomb DJ, Laurent G, Haigis MC.
Biochim Biophys Acta
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Mammalian sirtuins: biological insights and disease relevance.
Authors: Authors: Haigis MC, Sinclair DA.
Annu Rev Pathol
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The coordination of nuclear and mitochondrial communication during aging and calorie restriction.
Authors: Authors: Finley LW, Haigis MC.
Ageing Res Rev
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SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.
Authors: Authors: Nakagawa T, Lomb DJ, Haigis MC, Guarente L.
Cell
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Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
Authors: Authors: Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T.
Nat Genet
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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
Authors: Authors: Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B.
Mol Cell Biol
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Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction.
Authors: Authors: Haigis MC, Guarente LP.
Genes Dev
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SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.
Authors: Authors: Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L.
Cell
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