Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--
Cantley Lab

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Location of binding sites on the (Na,K)-ATPase for fluorescein-5'-isothiocyanate and ouabain.
Authors: Authors: Cantley L, Carilli CT, Farley RA, Perlman DM.
Ann N Y Acad Sci
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Mechanism of anion exchange across the red cell membrane by band 3: interactions between stilbenedisulfonate and NAP-taurine binding sites.
Authors: Authors: Macara IG, Cantley LC.
Biochemistry
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Interactions between transport inhibitors at the anion binding sites of the band 3 dimer.
Authors: Authors: Macara IG, Cantley LC.
Biochemistry
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Calcium regulates the commitment of murine erythroleukemia cells to terminal erythroid differentiation.
Authors: Authors: Bridges K, Levenson R, Housman D, Cantley L.
J Cell Biol
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A study of the vanadate-trapped state of the (Na,K)-ATPase. Evidence against interacting nucleotide site models.
Authors: Authors: Smith RL, Zinn K, Cantley LC.
J Biol Chem
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Amiloride inhibits murine erythroleukemia cell differentiation: evidence for a Ca2+ requirement for commitment.
Authors: Authors: Levenson R, Housman D, Cantley L.
Proc Natl Acad Sci U S A
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Structural changes in (Na+ + K+)-ATPase accompanying detergent inactivation.
Authors: Authors: Powell LD, Cantley LC.
Biochim Biophys Acta
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Glutathione reduces cytoplasmic vanadate. Mechanism and physiological implications.
Authors: Authors: Macara IG, Kustin K, Cantley LC.
Biochim Biophys Acta
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Location of the stilbenedisulfonate binding site of the human erythrocyte anion-exchange system by resonance energy transfer.
Authors: Authors: Rao A, Martin P, Reithmeier RA, Cantley LC.
Biochemistry
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The fate of cytoplasmic vanadium. Implications on (NA,K)-ATPase inhibition.
Authors: Authors: Cantley LC, Aisen P.
J Biol Chem
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