Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--
Cantley Lab

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications.
Authors: Authors: Cantley LC, Cantley LG, Josephson L.
J Biol Chem
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Vanadate inhibits the red cell (Na+, K+) ATPase from the cytoplasmic side.
Authors: Authors: Cantley LC, Resh MD, Guidotti G.
Nature
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Reaction of (Na-K)ATPase with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole: evidence for an essential tyrosine at the active site.
Authors: Authors: Cantley LC, Gelles J, Josephson L.
Biochemistry
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Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle.
Authors: Authors: Cantley LC, Josephson L, Warner R, Yanagisawa M, Lechene C, Guidotti G.
J Biol Chem
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Isolation of a potent (Na-K)ATPase inhibitor from striated muscle.
Authors: Authors: Josephson L, Cantley LC.
Biochemistry
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A slow interconversion between active and inactive states of the (Na-K)ATPase.
Authors: Authors: Cantley LC, Josephson L.
Biochemistry
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Characterization of sulfhydryl groups on chloroplast coupling factor 1 exposed by heat activation.
Authors: Authors: Cantley LC, Hammes GG.
Biochemistry
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Investigation of quercetin binding sites on chloroplast coupling factor 1.
Authors: Authors: Cantley LC, Hammes GG.
Biochemistry
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Characterization of nucleotide binding sites on chloroplast coupling factor 1.
Authors: Authors: Cantley LC, Hammes GG.
Biochemistry
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Fluorescence energy transfer between ligand binding sites on chloroplast coupling factor 1.
Authors: Authors: Cantley LC, Hammes GG.
Biochemistry
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