Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--
Cantley Lab

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

The plasma membrane (Mg2+)-dependent adenosine triphosphatase from the human erythrocyte is not an ion pump.
Authors: Authors: Forgac M, Cantley L.
J Membr Biol
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Increasing the intracellular Na+ concentration induces differentiation in a pre-B lymphocyte cell line.
Authors: Authors: Rosoff PM, Cantley LC.
Proc Natl Acad Sci U S A
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Vanadium stimulates the (Na+,K+) pump in friend erythroleukemia cells and blocks erythropoiesis.
Authors: Authors: English LH, Macara IG, Cantley LC.
J Cell Biol
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Phosphorylation of the (Na,K)-ATPase by a plasma membrane-bound protein kinase in friend erythroleukemia cells.
Authors: Authors: Yeh LA, Ling L, English L, Cantley L.
J Biol Chem
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Clathrin-coated vesicles contain an ATP-dependent proton pump.
Authors: Authors: Forgac M, Cantley L, Wiedenmann B, Altstiel L, Branton D.
Proc Natl Acad Sci U S A
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Evidence that inhibitors of anion exchange induce a transmembrane conformational change in band 3.
Authors: Authors: Macara IG, Kuo S, Cantley LC.
J Biol Chem
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Ionic regulation of MEL cell commitment.
Authors: Authors: Levenson R, Macara I, Cantley L, Housman D.
J Cell Biochem
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The active site structure of Na+- and K+-stimulated ATPase. Location of a specific fluorescein isothiocyanate reactive site.
Authors: Authors: Carilli CT, Farley RA, Perlman DM, Cantley LC.
J Biol Chem
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Role of mitochondrial membrane potential in the regulation of murine erythroleukemia cell differentiation.
Authors: Authors: Levenson R, Macara IG, Smith RL, Cantley L, Housman D.
Cell
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Evidence that a Na+/Ca2+ antiport system regulates murine erythroleukemia cell differentiation.
Authors: Authors: Smith RL, Macara IG, Levenson R, Housman D, Cantley L.
J Biol Chem
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