Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--
Cantley Lab

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Delta endotoxin inhibits Rb+ uptake, lowers cytoplasmic pH and inhibits a K+-ATPase in Manduca sexta CHE cells.
Authors: Authors: English LH, Cantley LC.
J Membr Biol
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Hypothalamic sodium-transport inhibitor is a high-affinity reversible inhibitor of Na+-K+-ATPase.
Authors: Authors: Haupert GT, Carilli CT, Cantley LC.
Am J Physiol
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Inositol 1,4,5-trisphosphate stimulates phosphorylation of a 62,000-dalton protein in monkey fibroblast and bovine brain cell lysates.
Authors: Authors: Whitman MR, Epstein J, Cantley L.
J Biol Chem
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Extracellular ATP induces ion fluxes and inhibits growth of Friend erythroleukemia cells.
Authors: Authors: Chahwala SB, Cantley LC.
J Biol Chem
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Characterization of a Ca2+-stimulated Mg2+-dependent adenosine triphosphatase in Friend murine erythroleukemia cell plasma membranes.
Authors: Authors: Debetto P, Cantley L.
J Biol Chem
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Characterization of monovalent ion transport systems in an insect cell line (Manduca sexta embryonic cell line CHE).
Authors: Authors: English LH, Cantley LC.
J Cell Physiol
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Characterization of the ATP-dependent proton pump of clathrin-coated vesicles.
Authors: Authors: Forgac M, Cantley L.
J Biol Chem
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Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.
Authors: Authors: Rosoff PM, Stein LF, Cantley LC.
J Biol Chem
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The (Na,K)-ATPase of Friend erythroleukemia cells is phosphorylated near the ATP hydrolysis by an endogenous membrane-bound kinase.
Authors: Authors: Ling L, Cantley L.
J Biol Chem
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Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.
Authors: Authors: Sugimoto Y, Whitman M, Cantley LC, Erikson RL.
Proc Natl Acad Sci U S A
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