Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--
Cantley Lab

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Phosphatidylinositol kinases and cell transformation.
Authors: Authors: Cantley L, Whitman M, Kaplan DR, Chahwala SB, Fleischman L, Endemann G, Schaffhausen BS, Roberts TM.
Symp Fundam Cancer Res
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Structural aspects of the red cell anion exchange protein.
Authors: Authors: Jay D, Cantley L.
Annu Rev Biochem
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Stimulation of the T3-T cell receptor-associated Ca2+ influx enhances the activity of the Na+/H+ exchanger in a leukemic human T cell line.
Authors: Authors: Rosoff PM, Cantley LC.
J Biol Chem
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Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes.
Authors: Authors: Rosoff PM, Cantley LC.
J Biol Chem
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Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation.
Authors: Authors: Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM.
Nature
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Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx.
Authors: Authors: Oettgen HC, Terhorst C, Cantley LC, Rosoff PM.
Cell
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Hypothalamic factor inhibits the (Na,K)ATPase from the extracellular surface. Mechanism of inhibition.
Authors: Authors: Carilli CT, Berne M, Cantley LC, Haupert GT.
J Biol Chem
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Expression of an ouabain resistance gene in transfected cells. Ouabain treatment induces a K+-transport system.
Authors: Authors: English LH, Epstein J, Cantley L, Housman D, Levenson R.
J Biol Chem
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The role of ion fluxes in hematopoietic cell differentiation.
Authors: Authors: Rosoff PM, Cantley LC.
Prog Clin Biol Res
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Ion fluxes and differentiation in transformed cell lines.
Authors: Authors: Rosoff PM, Cantley LC.
Soc Gen Physiol Ser
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