Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--
Cantley Lab

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

The role of lipid-derived second messengers in cell growth and transformation.
Authors: Authors: Cantley L, Fleischman L, Whitman M.
Anticancer Drug Des
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Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation.
Authors: Authors: Whitman M, Kaplan D, Roberts T, Cantley L.
Biochem J
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Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity.
Authors: Authors: Kaplan DR, Whitman M, Schaffhausen B, Pallas DC, White M, Cantley L, Roberts TM.
Cell
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Kinetic analysis of guanosine 5'-O-(3-thiotriphosphate) effects on phosphatidylinositol turnover in NRK cell homogenates.
Authors: Authors: Chahwala SB, Fleischman LF, Cantley L.
Biochemistry
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Phosphoinositide kinase activity and transformation.
Authors: Authors: Whitman M, Kaplan D, Cantley L, Roberts TM, Schaffhausen B.
Fed Proc
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Protein kinase C of human erythrocytes phosphorylates bands 4.1 and 4.9.
Authors: Authors: Faquin WC, Chahwala SB, Cantley LC, Branton D.
Biochim Biophys Acta
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Phosphatidylinositol metabolism and polyoma-mediated transformation.
Authors: Authors: Kaplan DR, Whitman M, Schaffhausen B, Raptis L, Garcea RL, Pallas D, Roberts TM, Cantley L.
Proc Natl Acad Sci U S A
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Delta endotoxin is a potent inhibitor of the (Na,K)-ATPase.
Authors: Authors: English LH, Cantley LC.
J Biol Chem
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ras-transformed cells: altered levels of phosphatidylinositol-4,5-bisphosphate and catabolites.
Authors: Authors: Fleischman LF, Chahwala SB, Cantley L.
Science
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Oncogenes and phosphatidylinositol turnover.
Authors: Authors: Cantley LC, Whitman M, Chahwala S, Fleischman L, Kaplan DR, Schaffhausen BS, Roberts TM.
Ann N Y Acad Sci
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