Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--
Cantley Lab

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Cell cycle dependence of inositol phosphate levels in neuroblastoma cells.
Authors: Authors: Fleischman LF, Cantley L.
Am J Physiol
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Expression of an ouabain-resistant Na,K-ATPase in CV-1 cells after transfection with a cDNA encoding the rat Na,K-ATPase alpha 1 subunit.
Authors: Authors: Emanuel JR, Schulz J, Zhou XM, Kent RB, Housman D, Cantley L, Levenson R.
J Biol Chem
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Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C.
Authors: Authors: Varticovski L, Chahwala SB, Whitman M, Cantley L, Schindler D, Chow EP, Sinclair LK, Pepinsky RB.
Biochemistry
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Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate.
Authors: Authors: Whitman M, Downes CP, Keeler M, Keller T, Cantley L.
Nature
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CV-1 cell recipients of the mouse ouabain resistance gene express a ouabain-insensitive Na,K-ATPase after growth in cardioactive steroids.
Authors: Authors: Schulz JT, Cantley LC.
J Biol Chem
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Growth factor and oncogene influences on cell growth regulation.
Authors: Authors: Serunian LA, Cantley LC.
Ann N Y Acad Sci
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Mitogens and ion fluxes.
Authors: Authors: Soltoff SP, Cantley LC.
Annu Rev Physiol
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Extracellular ATP elevates intracellular free calcium in rat parotid acinar cells.
Authors: Authors: McMillian MK, Soltoff SP, Cantley LC, Talamo BR.
Biochem Biophys Res Commun
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Membrane biochemistry of the ouabain-resistant potassium transport system.
Authors: Authors: English LH, White B, Cantley LC.
Hypertension
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Bovine brain contains two types of phosphatidylinositol kinase.
Authors: Authors: Endemann G, Dunn SN, Cantley LC.
Biochemistry
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