Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--
Cantley Lab

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Effects of extracellular ATP on ion transport systems and [Ca2+]i in rat parotid acinar cells. Comparison with the muscarinic agonist carbachol.
Authors: Authors: Soltoff SP, McMillian MK, Cragoe EJ, Cantley LC, Talamo BR.
J Gen Physiol
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Elevation of [Ca2+]i and the activation of ion channels and fluxes by extracellular ATP and phospholipase C-linked agonists in rat parotid acinar cells.
Authors: Authors: Soltoff SP, McMillian MK, Lechleiter JD, Cantley LC, Talamo BR.
Ann N Y Acad Sci
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The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase.
Authors: Authors: Varticovski L, Druker B, Morrison D, Cantley L, Roberts T.
Nature
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Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae.
Authors: Authors: Auger KR, Carpenter CL, Cantley LC, Varticovski L.
J Biol Chem
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Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain.
Authors: Authors: Serunian LA, Haber MT, Fukui T, Kim JW, Rhee SG, Lowenstein JM, Cantley LC.
J Biol Chem
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PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells.
Authors: Authors: Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC.
Cell
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Characterization and purification of membrane-associated phosphatidylinositol-4-phosphate kinase from human red blood cells.
Authors: Authors: Ling LE, Schulz JT, Cantley LC.
J Biol Chem
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Effects of muscarinic, alpha-adrenergic, and substance P agonists and ionomycin on ion transport mechanisms in the rat parotid acinar cell. The dependence of ion transport on intracellular calcium.
Authors: Authors: Soltoff SP, McMillian MK, Cantley LC, Cragoe EJ, Talamo BR.
J Gen Physiol
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Phosphoinositide metabolism and the control of cell proliferation.
Authors: Authors: Whitman M, Cantley L.
Biochim Biophys Acta
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Cell cycle dependence of inositol phosphate levels in neuroblastoma cells.
Authors: Authors: Fleischman LF, Cantley L.
Am J Physiol
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