Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--
Cantley Lab

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.
Authors: Authors: Varticovski L, Daley GQ, Jackson P, Baltimore D, Cantley LC.
Mol Cell Biol
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Oncogenes and signal transduction.
Authors: Authors: Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S.
Cell
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A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase.
Authors: Authors: Endemann GC, Graziani A, Cantley LC.
Biochem J
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Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation.
Authors: Authors: Serunian LA, Auger KR, Cantley LC.
Methods Enzymol
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Phosphoinositide kinases.
Authors: Authors: Carpenter CL, Cantley LC.
Biochemistry
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A novel pathway for the formation of phosphatidylinositol 3,4-bisphosphate. Phosphorylation of phosphatidylinositol 3-monophosphate by phosphatidylinositol-3-monophosphate 4-kinase.
Authors: Authors: Yamamoto K, Graziani A, Carpenter C, Cantley LC, Lapetina EG.
J Biol Chem
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Purification and characterization of phosphoinositide 3-kinase from rat liver.
Authors: Authors: Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC.
J Biol Chem
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Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen.
Authors: Authors: Serunian LA, Auger KR, Roberts TM, Cantley LC.
J Virol
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Activation of phosphatidylinositol 3-kinase by insulin.
Authors: Authors: Ruderman NB, Kapeller R, White MF, Cantley LC.
Proc Natl Acad Sci U S A
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Effects of extracellular ATP on ion transport systems and [Ca2+]i in rat parotid acinar cells. Comparison with the muscarinic agonist carbachol.
Authors: Authors: Soltoff SP, McMillian MK, Cragoe EJ, Cantley LC, Talamo BR.
J Gen Physiol
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