Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--
Cantley Lab

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase.
Authors: Authors: Soltoff SP, Rabin SL, Cantley LC, Kaplan DR.
J Biol Chem
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Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes.
Authors: Authors: Graziani A, Ling LE, Endemann G, Carpenter CL, Cantley LC.
Biochem J
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Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro.
Authors: Authors: Auger KR, Carpenter CL, Shoelson SE, Piwnica-Worms H, Cantley LC.
J Biol Chem
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Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells.
Authors: Authors: Ling LE, Druker BJ, Cantley LC, Roberts TM.
J Virol
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Phosphatidylinositol-3 kinase and growth regulation.
Authors: Authors: Soltoff SP, Carpenter CL, Auger KR, Kapeller R, Schaffhausen B, Cantley LC.
Cold Spring Harb Symp Quant Biol
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The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase.
Authors: Authors: Graziani A, Gramaglia D, Cantley LC, Comoglio PM.
J Biol Chem
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Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase.
Authors: Authors: Remillard B, Petrillo R, Maslinski W, Tsudo M, Strom TB, Cantley L, Varticovski L.
J Biol Chem
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Rapid release of bound glucose-6-phosphate dehydrogenase by growth factors. Correlation with increased enzymatic activity.
Authors: Authors: Stanton RC, Seifter JL, Boxer DC, Zimmerman E, Cantley LC.
J Biol Chem
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Novel polyphosphoinositides in cell growth and activation.
Authors: Authors: Auger KR, Cantley LC.
Cancer Cells
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Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin.
Authors: Authors: Kapeller R, Chen KS, Yoakim M, Schaffhausen BS, Backer J, White MF, Cantley LC, Ruderman NB.
Mol Endocrinol
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