Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--
Cantley Lab

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.
Authors: Authors: Prasad KV, Janssen O, Kapeller R, Raab M, Cantley LC, Rudd CE.
Proc Natl Acad Sci U S A
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Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells.
Authors: Authors: Corey S, Eguinoa A, Puyana-Theall K, Bolen JB, Cantley L, Mollinedo F, Jackson TR, Hawkins PT, Stephens LR.
EMBO J
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Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit.
Authors: Authors: Carpenter CL, Auger KR, Chanudhuri M, Yoakim M, Schaffhausen B, Shoelson S, Cantley LC.
J Biol Chem
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Blockade of ATP binding site of P2 purinoceptors in rat parotid acinar cells by isothiocyanate compounds.
Authors: Authors: Soltoff SP, McMillian MK, Talamo BR, Cantley LC.
Biochem Pharmacol
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Regulation of c-Src tyrosine kinase activity by the Src SH2 domain.
Authors: Authors: Liu X, Brodeur SR, Gish G, Songyang Z, Cantley LC, Laudano AP, Pawson T.
Oncogene
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SH2 domains recognize specific phosphopeptide sequences.
Authors: Authors: Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, et al.
Cell
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A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity.
Authors: Authors: Carpenter CL, Auger KR, Duckworth BC, Hou WM, Schaffhausen B, Cantley LC.
Mol Cell Biol
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A murine genomic DNA fragment amplifies ouabain-induced Na,K-ATPase alpha/beta-subunit mRNA up-regulation and confers ouabain resistance.
Authors: Authors: Zhou XM, Cunha MJ, Epstein J, Levenson R, Cantley LC, Cantley LG.
J Biol Chem
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Two distinct cytosolic calcium responses to extracellular ATP in rat parotid acinar cells.
Authors: Authors: McMillian MK, Soltoff SP, Cantley LC, Rudel R, Talamo BR.
Br J Pharmacol
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Ouabain-resistant transfectants of the murine ouabain resistance gene contain mutations in the alpha-subunit of the Na,K-ATPase.
Authors: Authors: Cantley LG, Zhou XM, Cunha MJ, Epstein J, Cantley LC.
J Biol Chem
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