Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--
Cantley Lab

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.
Authors: Authors: Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al.
Mol Cell Biol
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T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.
Authors: Authors: Prasad KV, Cai YC, Raab M, Duckworth B, Cantley L, Shoelson SE, Rudd CE.
Proc Natl Acad Sci U S A
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Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction.
Authors: Authors: Kanakaraj P, Duckworth B, Azzoni L, Kamoun M, Cantley LC, Perussia B.
J Exp Med
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Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.
Authors: Authors: Kapeller R, Prasad KV, Janssen O, Hou W, Schaffhausen BS, Rudd CE, Cantley LC.
J Biol Chem
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Specificity in recognition of phosphopeptides by src-homology 2 domains.
Authors: Authors: Cantley LC, Songyang Z.
J Cell Sci Suppl
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Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.
Authors: Authors: Prasad KV, Kapeller R, Janssen O, Repke H, Duke-Cohan JS, Cantley LC, Rudd CE.
Mol Cell Biol
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Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation.
Authors: Authors: Ravichandran KS, Lee KK, Songyang Z, Cantley LC, Burn P, Burakoff SJ.
Science
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Regulation of CD4-p56lck-associated phosphatidylinositol 3-kinase (PI 3-kinase) and phosphatidylinositol 4-kinase (PI 4-kinase).
Authors: Authors: Prasad KV, Kapeller R, Janssen O, Duke-Cohan JS, Repke H, Cantley LC, Rudd CE.
Philos Trans R Soc Lond B Biol Sci
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Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton.
Authors: Authors: Kapeller R, Chakrabarti R, Cantley L, Fay F, Corvera S.
Mol Cell Biol
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Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.
Authors: Authors: Birge RB, Fajardo JE, Reichman C, Shoelson SE, Songyang Z, Cantley LC, Hanafusa H.
Mol Cell Biol
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