Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--
Cantley Lab

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity.
Authors: Authors: Yoakim M, Hou W, Songyang Z, Liu Y, Cantley L, Schaffhausen B.
Mol Cell Biol
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Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn.
Authors: Authors: Panchamoorthy G, Fukazawa T, Stolz L, Payne G, Reedquist K, Shoelson S, Songyang Z, Cantley L, Walsh C, Band H.
Mol Cell Biol
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Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D.
Authors: Authors: Liscovitch M, Chalifa V, Pertile P, Chen CS, Cantley LC.
J Biol Chem
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Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.
Authors: Authors: Guy PM, Platko JV, Cantley LC, Cerione RA, Carraway KL.
Proc Natl Acad Sci U S A
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Phosphatidylinositol 3-kinase.
Authors: Authors: Kapeller R, Cantley LC.
Bioessays
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A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling.
Authors: Authors: Carraway KL, Cantley LC.
Cell
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SH2 domain specificity and activity modified by a single residue.
Authors: Authors: Marengere LE, Songyang Z, Gish GD, Schaller MD, Parsons JT, Stern MJ, Cantley LC, Pawson T.
Nature
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ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.
Authors: Authors: Soltoff SP, Carraway KL, Prigent SA, Gullick WG, Cantley LC.
Mol Cell Biol
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The erbB3 gene product is a receptor for heregulin.
Authors: Authors: Carraway KL, Sliwkowski MX, Akita R, Platko JV, Guy PM, Nuijens A, Diamonti AJ, Vandlen RL, Cantley LC, Cerione RA.
J Biol Chem
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Lipid second messengers.
Authors: Authors: Liscovitch M, Cantley LC.
Cell
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