Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--
Cantley Lab

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.
Authors: Authors: Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M.
Oncogene
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Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3.
Authors: Authors: Carraway KL, Soltoff SP, Diamonti AJ, Cantley LC.
J Biol Chem
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Phosphatidylinositol 4,5-bisphosphate synthesis is required for activation of phospholipase D in U937 cells.
Authors: Authors: Pertile P, Liscovitch M, Chalifa V, Cantley LC.
J Biol Chem
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Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals.
Authors: Authors: Klingmüller U, Lorenz U, Cantley LC, Neel BG, Lodish HF.
Cell
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Catalytic specificity of protein-tyrosine kinases is critical for selective signalling.
Authors: Authors: Songyang Z, Carraway KL, Eck MJ, Harrison SC, Feldman RA, Mohammadi M, Schlessinger J, Hubbard SR, Smith DP, Eng C, et al.
Nature
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SH2 domain specificity determination using oriented phosphopeptide library.
Authors: Authors: Songyang Z, Cantley LC.
Methods Enzymol
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Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.
Authors: Authors: Toker A, Meyer M, Reddy KK, Falck JR, Aneja R, Aneja S, Parra A, Burns DJ, Ballas LM, Cantley LC.
J Biol Chem
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Cloning and characterization of a human phosphatidylinositol 4-kinase.
Authors: Authors: Wong K, Cantley LC.
J Biol Chem
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Use of an oriented peptide library to determine the optimal substrates of protein kinases.
Authors: Authors: Songyang Z, Blechner S, Hoagland N, Hoekstra MF, Piwnica-Worms H, Cantley LC.
Curr Biol
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Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.
Authors: Authors: Jhun BH, Rose DW, Seely BL, Rameh L, Cantley L, Saltiel AR, Olefsky JM.
Mol Cell Biol
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