Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--
Cantley Lab

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin.
Authors: Authors: Kapeller R, Toker A, Cantley LC, Carpenter CL.
J Biol Chem
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Identification of efficient pentapeptide substrates for the tyrosine kinase pp60c-src.
Authors: Authors: Nair SA, Kim MH, Warren SD, Choi S, Songyang Z, Cantley LC, Hangauer DG.
J Med Chem
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T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38.
Authors: Authors: Fukazawa T, Reedquist KA, Panchamoorthy G, Soltoff S, Trub T, Druker B, Cantley L, Shoelson SE, Band H.
J Biol Chem
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The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase.
Authors: Authors: Fukazawa T, Reedquist KA, Trub T, Soltoff S, Panchamoorthy G, Druker B, Cantley L, Shoelson SE, Band H.
J Biol Chem
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Rho family GTPases bind to phosphoinositide kinases.
Authors: Authors: Tolias KF, Cantley LC, Carpenter CL.
J Biol Chem
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The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif.
Authors: Authors: Songyang Z, Margolis B, Chaudhuri M, Shoelson SE, Cantley LC.
J Biol Chem
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Signal transduction and membrane traffic: the PITP/phosphoinositide connection.
Authors: Authors: Liscovitch M, Cantley LC.
Cell
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Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation.
Authors: Authors: Kovacsovics TJ, Bachelot C, Toker A, Vlahos CJ, Duckworth B, Cantley LC, Hartwig JH.
J Biol Chem
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Signal transduction by the hepatocyte growth factor receptor, c-met. Activation of the phosphatidylinositol 3-kinase.
Authors: Authors: Cantley LG, Cantley LC.
J Am Soc Nephrol
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Type 2 phosphatidylinositol 4-kinase is recruited to CD4 in response to CD4 cross-linking.
Authors: Authors: Pertile P, Cantley LC.
Biochim Biophys Acta
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