Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Binding specificity and mutational analysis of the phosphotyrosine binding domain of the brain-specific adaptor protein ShcC.
Authors: Authors: O'Bryan JP, Martin CB, Songyang Z, Cantley LC, Der CJ.
J Biol Chem
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A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain.
Authors: Authors: O'Bryan JP, Songyang Z, Cantley L, Der CJ, Pawson T.
Proc Natl Acad Sci U S A
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Phosphoinositide kinases.
Authors: Authors: Carpenter CL, Cantley LC.
Curr Opin Cell Biol
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Association of phosphatidylinositol 3-kinase, via the SH2 domains of p85, with focal adhesion kinase in polyoma middle t-transformed fibroblasts.
Authors: Authors: Bachelot C, Rameh L, Parsons T, Cantley LC.
Biochim Biophys Acta
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p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase.
Authors: Authors: Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B, Shoelson S, Cantley L, Band H.
J Biol Chem
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p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells.
Authors: Authors: Soltoff SP, Cantley LC.
J Biol Chem
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Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase.
Authors: Authors: Toker A, Bachelot C, Chen CS, Falck JR, Hartwig JH, Cantley LC, Kovacsovics TJ.
J Biol Chem
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Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins.
Authors: Authors: Rameh LE, Chen CS, Cantley LC.
Cell
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A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains.
Authors: Authors: Songyang Z, Gish G, Mbamalu G, Pawson T, Cantley LC.
J Biol Chem
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Recognition and specificity in protein tyrosine kinase-mediated signalling.
Authors: Authors: Songyang Z, Cantley LC.
Trends Biochem Sci
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