Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit.
Authors: Authors: Musacchio A, Cantley LC, Harrison SC.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation.
Authors: Authors: Osborne MA, Zenner G, Lubinus M, Zhang X, Songyang Z, Cantley LC, Majerus P, Burn P, Kochan JP.
J Biol Chem
View full abstract on Pubmed
Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes.
Authors: Authors: Boll W, Ohno H, Songyang Z, Rapoport I, Cantley LC, Bonifacino JS, Kirchhausen T.
EMBO J
View full abstract on Pubmed
A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.
Authors: Authors: Songyang Z, Lu KP, Kwon YT, Tsai LH, Filhol O, Cochet C, Brickey DA, Soderling TR, Bartleson C, Graves DJ, DeMaggio AJ, Hoekstra MF, Blenis J, Hunter T, Cantley LC.
Mol Cell Biol
View full abstract on Pubmed
Regulation of the Lck SH2 domain by tyrosine phosphorylation.
Authors: Authors: Couture C, Songyang Z, Jascur T, Williams S, Tailor P, Cantley LC, Mustelin T.
J Biol Chem
View full abstract on Pubmed
Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity.
Authors: Authors: Klinghoffer RA, Duckworth B, Valius M, Cantley L, Kazlauskas A.
Mol Cell Biol
View full abstract on Pubmed
Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene.
Authors: Authors: Fruman DA, Cantley LC, Carpenter CL.
Genomics
View full abstract on Pubmed
Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.
Authors: Authors: Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S.
J Biol Chem
View full abstract on Pubmed
Phosphoinositide 3-kinase and the regulation of cell growth.
Authors: Authors: Carpenter CL, Cantley LC.
Biochim Biophys Acta
View full abstract on Pubmed
Specificity of LIM domain interactions with receptor tyrosine kinases.
Authors: Authors: Wu R, Durick K, Songyang Z, Cantley LC, Taylor SS, Gill GN.
J Biol Chem
View full abstract on Pubmed