Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Cell regulation.
Authors: Authors: Cantley LC, Coughlin SR.
Curr Opin Cell Biol
View full abstract on Pubmed
The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C.
Authors: Authors: Derman MP, Toker A, Hartwig JH, Spokes K, Falck JR, Chen CS, Cantley LC, Cantley LG.
J Biol Chem
View full abstract on Pubmed
PI3K: downstream AKTion blocks apoptosis.
Authors: Authors: Franke TF, Kaplan DR, Cantley LC.
Cell
View full abstract on Pubmed
Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase.
Authors: Authors: Meyers R, Cantley LC.
J Biol Chem
View full abstract on Pubmed
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate.
Authors: Authors: Franke TF, Kaplan DR, Cantley LC, Toker A.
Science
View full abstract on Pubmed
Determination of the specific substrate sequence motifs of protein kinase C isozymes.
Authors: Authors: Nishikawa K, Toker A, Johannes FJ, Songyang Z, Cantley LC.
J Biol Chem
View full abstract on Pubmed
Recognition of unique carboxyl-terminal motifs by distinct PDZ domains.
Authors: Authors: Songyang Z, Fanning AS, Fu C, Xu J, Marfatia SM, Chishti AH, Crompton A, Chan AC, Anderson JM, Cantley LC.
Science
View full abstract on Pubmed
Specificity in protein-tyrosine kinase signaling.
Authors: Authors: Cantley LC, Songyang Z.
Adv Second Messenger Phosphoprotein Res
View full abstract on Pubmed
Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2.
Authors: Authors: Vikkula M, Boon LM, Carraway KL, Calvert JT, Diamonti AJ, Goumnerov B, Pasyk KA, Marchuk DA, Warman ML, Cantley LC, Mulliken JB, Olsen BR.
Cell
View full abstract on Pubmed
D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate.
Authors: Authors: Hartwig JH, Kung S, Kovacsovics T, Janmey PA, Cantley LC, Stossel TP, Toker A.
J Biol Chem
View full abstract on Pubmed