Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains.
Authors: Authors: Rameh LE, Arvidsson Ak, Carraway KL, Couvillon AD, Rathbun G, Crompton A, VanRenterghem B, Czech MP, Ravichandran KS, Burakoff SJ, Wang DS, Chen CS, Cantley LC.
J Biol Chem
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High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif.
Authors: Authors: Li SC, Songyang Z, Vincent SJ, Zwahlen C, Wiley S, Cantley L, Kay LE, Forman-Kay J, Pawson T.
Proc Natl Acad Sci U S A
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Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells.
Authors: Authors: Holland SJ, Gale NW, Gish GD, Roth RA, Songyang Z, Cantley LC, Henkemeyer M, Yancopoulos GD, Pawson T.
EMBO J
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Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase.
Authors: Authors: Chang HW, Aoki M, Fruman D, Auger KR, Bellacosa A, Tsichlis PN, Cantley LC, Roberts TM, Vogt PK.
Science
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Signalling through the lipid products of phosphoinositide-3-OH kinase.
Authors: Authors: Toker A, Cantley LC.
Nature
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Sequence specificity of C-terminal Src kinase (CSK)--a comparison with Src-related kinases c-Fgr and Lyn.
Authors: Authors: Ruzzene M, Songyang Z, Marin O, Donella-Deana A, Brunati AM, Guerra B, Agostinis P, Cantley LC, Pinna LA.
Eur J Biochem
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Subcellular locations of phosphatidylinositol 4-kinase isoforms.
Authors: Authors: Wong K, Cantley LC.
J Biol Chem
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The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence.
Authors: Authors: Grabs D, Slepnev VI, Songyang Z, David C, Lynch M, Cantley LC, De Camilli P.
J Biol Chem
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Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes.
Authors: Authors: Rapoport I, Miyazaki M, Boll W, Duckworth B, Cantley LC, Shoelson S, Kirchhausen T.
EMBO J
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Cell regulation.
Authors: Authors: Cantley LC, Coughlin SR.
Curr Opin Cell Biol
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