Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

The use of peptide library for the determination of kinase peptide substrates.
Authors: Authors: Songyang Z, Cantley LC.
Methods Mol Biol
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Phosphoinositide kinases.
Authors: Authors: Fruman DA, Meyers RE, Cantley LC.
Annu Rev Biochem
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The structural basis for 14-3-3:phosphopeptide binding specificity.
Authors: Authors: Yaffe MB, Rittinger K, Volinia S, Caron PR, Aitken A, Leffers H, Gamblin SJ, Smerdon SJ, Cantley LC.
Cell
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The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.
Authors: Authors: Lupher ML, Songyang Z, Shoelson SE, Cantley LC, Band H.
J Biol Chem
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Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism.
Authors: Authors: Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld JU, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP.
Science
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A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.
Authors: Authors: Rameh LE, Tolias KF, Duckworth BC, Cantley LC.
Nature
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Apoptosis. A Bad kinase makes good.
Authors: Authors: Franke TF, Cantley LC.
Nature
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Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.
Authors: Authors: Borgatti P, Zauli G, Colamussi ML, Gibellini D, Previati M, Cantley LL, Capitani S.
Eur J Immunol
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Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength.
Authors: Authors: Duckworth BC, Cantley LC.
J Biol Chem
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Interleukin 3-dependent survival by the Akt protein kinase.
Authors: Authors: Songyang Z, Baltimore D, Cantley LC, Kaplan DR, Franke TF.
Proc Natl Acad Sci U S A
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