Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling.
Authors: Authors: Beitz LO, Fruman DA, Kurosaki T, Cantley LC, Scharenberg AM.
J Biol Chem
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Signal transduction. Grabbing phosphoproteins.
Authors: Authors: Yaffe MB, Cantley LC.
Nature
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Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Authors: Authors: Poy F, Yaffe MB, Sayos J, Saxena K, Morra M, Sumegi J, Cantley LC, Terhorst C, Eck MJ.
Mol Cell
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Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.
Authors: Authors: Aramburu J, Yaffe MB, López-Rodríguez C, Cantley LC, Hogan PG, Rao A.
Science
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Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B.
Authors: Authors: Aksoy IA, Ramsey MJ, Fruman DA, Aksoy S, Cantley LC, Tucker JD, Roberts TM.
Biochem Biophys Res Commun
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Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding.
Authors: Authors: Rittinger K, Budman J, Xu J, Volinia S, Cantley LC, Smerdon SJ, Gamblin SJ, Yaffe MB.
Mol Cell
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Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation.
Authors: Authors: Fruman DA, Snapper SB, Yballe CM, Alt FW, Cantley LC.
Biochem Soc Trans
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Phosphoinositide binding domains: embracing 3-phosphate.
Authors: Authors: Fruman DA, Rameh LE, Cantley LC.
Cell
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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.
Authors: Authors: Cantley LC, Neel BG.
Proc Natl Acad Sci U S A
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Pathways for phosphoinositide synthesis.
Authors: Authors: Tolias KF, Cantley LC.
Chem Phys Lipids
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