Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells.
Authors: Authors: O'Rourke DA, Sakurai H, Spokes K, Kjelsberg C, Takahashi M, Nigam S, Cantley L.
Am J Physiol
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The role of phosphoinositide 3-kinase lipid products in cell function.
Authors: Authors: Rameh LE, Cantley LC.
J Biol Chem
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The SH2 domain-containing inositol 5'-phosphatase (SHIP) recruits the p85 subunit of phosphoinositide 3-kinase during FcgammaRIIb1-mediated inhibition of B cell receptor signaling.
Authors: Authors: Gupta N, Scharenberg AM, Fruman DA, Cantley LC, Kinet JP, Long EO.
J Biol Chem
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Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.
Authors: Authors: Fruman DA, Snapper SB, Yballe CM, Davidson L, Yu JY, Alt FW, Cantley LC.
Science
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ATM and lymphoid malignancies; use of oriented peptide libraries to identify novel substrates of ATM critical in downstream signaling pathways.
Authors: Authors: Rathbun GA, Ziv Y, Lai JH, Hill D, Abraham RH, Shiloh Y, Cantley LC.
Curr Top Microbiol Immunol
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Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2.
Authors: Authors: Crovello CS, Lai C, Cantley LC, Carraway KL.
J Biol Chem
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A flattened face for membranes.
Authors: Authors: Carpenter CL, Cantley LC.
Nat Struct Biol
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Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling.
Authors: Authors: Rameh LE, Rhee SG, Spokes K, Kazlauskas A, Cantley LC, Cantley LG.
J Biol Chem
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Association of protein kinase Cmu with type II phosphatidylinositol 4-kinase and type I phosphatidylinositol-4-phosphate 5-kinase.
Authors: Authors: Nishikawa K, Toker A, Wong K, Marignani PA, Johannes FJ, Cantley LC.
J Biol Chem
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Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation.
Authors: Authors: Parker D, Jhala US, Radhakrishnan I, Yaffe MB, Reyes C, Shulman AI, Cantley LC, Wright PE, Montminy M.
Mol Cell
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