Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase.
Authors: Authors: Nishikawa K, Sawasdikosol S, Fruman DA, Lai J, Songyang Z, Burakoff SJ, Yaffe MB, Cantley LC.
Mol Cell
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Minimal activators that bind to the KIX domain of p300/CBP identified by phage display screening.
Authors: Authors: Frangioni JV, LaRiccia LM, Cantley LC, Montminy MR.
Nat Biotechnol
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Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.
Authors: Authors: O'Neill T, Dwyer AJ, Ziv Y, Chan DW, Lees-Miller SP, Abraham RH, Lai JH, Hill D, Shiloh Y, Cantley LC, Rathbun GA.
J Biol Chem
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Ligand discrimination in signaling through an ErbB4 receptor homodimer.
Authors: Authors: Sweeney C, Lai C, Riese DJ, Diamonti AJ, Cantley LC, Carraway KL.
J Biol Chem
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A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.
Authors: Authors: Satterthwaite AB, Willis F, Kanchanastit P, Fruman D, Cantley LC, Helgason CD, Humphries RK, Lowell CA, Simon M, Leitges M, Tarakhovsky A, Tedder TF, Lesche R, Wu H, Witte ON.
Proc Natl Acad Sci U S A
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The conserved phosphoinositide 3-kinase pathway determines heart size in mice.
Authors: Authors: Shioi T, Kang PM, Douglas PS, Hampe J, Yballe CM, Lawitts J, Cantley LC, Izumo S.
EMBO J
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Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products.
Authors: Authors: Lu-Kuo JM, Fruman DA, Joyal DM, Cantley LC, Katz HR.
J Biol Chem
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Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly.
Authors: Authors: Tolias KF, Hartwig JH, Ishihara H, Shibasaki Y, Cantley LC, Carpenter CL.
Curr Biol
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Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade.
Authors: Authors: Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ.
J Biol Chem
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Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries.
Authors: Authors: Yaffe MB, Cantley LC.
Methods Enzymol
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