Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Determination of protease cleavage site motifs using mixture-based oriented peptide libraries.
Authors: Authors: Turk BE, Huang LL, Piro ET, Cantley LC.
Nat Biotechnol
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The PX domains of p47phox and p40phox bind to lipid products of PI(3)K.
Authors: Authors: Kanai F, Liu H, Field SJ, Akbary H, Matsuo T, Brown GE, Cantley LC, Yaffe MB.
Nat Cell Biol
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Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors.
Authors: Authors: Sweeney C, Fambrough D, Huard C, Diamonti AJ, Lander ES, Cantley LC, Carraway KL.
J Biol Chem
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Transcription. Translocating tubby.
Authors: Authors: Cantley LC.
Science
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The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.
Authors: Authors: Karuman P, Gozani O, Odze RD, Zhou XC, Zhu H, Shaw R, Brien TP, Bozzuto CD, Ooi D, Cantley LC, Yuan J.
Mol Cell
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Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity.
Authors: Authors: Bertenshaw GP, Turk BE, Hubbard SJ, Matters GL, Bylander JE, Crisman JM, Cantley LC, Bond JS.
J Biol Chem
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A motif-based profile scanning approach for genome-wide prediction of signaling pathways.
Authors: Authors: Yaffe MB, Leparc GG, Lai J, Obata T, Volinia S, Cantley LC.
Nat Biotechnol
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TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins.
Authors: Authors: Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB.
EMBO J
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Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.
Authors: Authors: Obata T, Yaffe MB, Leparc GG, Piro ET, Maegawa H, Kashiwagi A, Kikkawa R, Cantley LC.
J Biol Chem
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Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha.
Authors: Authors: Fruman DA, Mauvais-Jarvis F, Pollard DA, Yballe CM, Brazil D, Bronson RT, Kahn CR, Cantley LC.
Nat Genet
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