Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Interferon regulatory factor-3 is an in vivo target of DNA-PK.
Authors: Authors: Karpova AY, Trost M, Murray JM, Cantley LC, Howley PM.
Proc Natl Acad Sci U S A
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Phosphorylation by LAMMER protein kinases: determination of a consensus site, identification of in vitro substrates, and implications for substrate preferences.
Authors: Authors: Nikolakaki E, Du C, Lai J, Giannakouros T, Cantley L, Rabinow L.
Biochemistry
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Phosphoinositide 3-kinase in immunological systems.
Authors: Authors: Fruman DA, Cantley LC.
Semin Immunol
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Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.
Authors: Authors: Ueki K, Fruman DA, Brachmann SM, Tseng YH, Cantley LC, Kahn CR.
Mol Cell Biol
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Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase.
Authors: Authors: Ueki K, Yballe CM, Brachmann SM, Vicent D, Watt JM, Kahn CR, Cantley LC.
Proc Natl Acad Sci U S A
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Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.
Authors: Authors: Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR.
J Clin Invest
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In vivo near-infrared fluorescence imaging of osteoblastic activity.
Authors: Authors: Zaheer A, Lenkinski RE, Mahmood A, Jones AG, Cantley LC, Frangioni JV.
Nat Biotechnol
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Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis.
Authors: Authors: Singh VP, Saluja AK, Bhagat L, van Acker GJ, Song AM, Soltoff SP, Cantley LC, Steer ML.
J Clin Invest
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Phosphatidylinositol 3-kinase confers resistance to encephalomyocarditis and herpes simplex virus-induced cell death through the activation of distinct downstream effectors.
Authors: Authors: Prejean C, Sarma T, Kurnasov O, Usacheva A, Hemmings B, Cantley L, Fruman DA, Morrison LA, Buller RM, Colamonici OR.
J Immunol
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Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation.
Authors: Authors: Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, Davidson HW, Schreiber A, Backer JM, Cantley LC, Grinstein S.
J Cell Biol
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